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2 Result(s)
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Article
Open AccessTargeting p53 pathways: mechanisms, structures, and advances in therapy
The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has been a major focus of oncology research. The p53 protein is a transcription factor that can activate the expression of multi...
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Open AccessTargeting MCL-1 in cancer: current status and perspectives
Myeloid leukemia 1 (MCL-1) is an antiapoptotic protein of the BCL-2 family that prevents apoptosis by binding to the pro-apoptotic BCL-2 proteins. Overexpression of MCL-1 is frequently observed in many tumor t...
