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  1. No Access

    Article

    Down-regulation of RTEL1 Improves M1/M2 Macrophage Polarization by Promoting SFRP2 in Fibroblasts-derived Exosomes to Alleviate COPD

    Chronic obstructive pulmonary disease (COPD) is a common chronic respiratory disease worldwide. Macrophage polarization plays a substantial role in the pathogenesis of COPD. This study is aimed to explore the ...

    He-** Xu, Feng Zhan, Hong Wang, Jie Lin, Huan Niu in Cell Biochemistry and Biophysics (2024)

  2. Article

    Open Access

    UHMK1-dependent phosphorylation of Cajal body protein coilin alters 5-FU sensitivity in colon cancer cells

    Resistance to 5-fluorouracil (5-FU) in chemotherapy and recurrence of colorectal tumors is a serious concern that impedes improvements to clinical outcomes. In the present study, we found that conditioned medi...

    Huan Niu, Meng Zhao, **g Huang, **g Wang, Yang Si… in Cell Communication and Signaling (2022)

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  3. Article

    Open Access

    Epigenetic regulation of osteopontin splicing isoform c defines its role as a microenvironmental factor to promote the survival of colon cancer cells from 5-FU treatment

    Drug resistance to 5-fluorouracil (5-FU) and recurrence after chemotherapy in colorectal cancer remain a challenge to be resolved for the improvement of patient outcomes. It is recognized that a variety of sec...

    Siyuan Chang, **g Huang, Huan Niu, **g Wang, Yang Si… in Cancer Cell International (2020)

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