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    Rational design of a protein that binds integrin αvβ3 outside the ligand binding site

    Integrin αvβ3 expression is altered in various diseases and has been proposed as a drug target. Here we use a rational design approach to develop a therapeutic protein, which we call ProAgio, that binds to integr...

    Ravi Chakra Turaga, Lu Yin, Jenny J. Yang, Hsiauwei Lee… in Nature Communications (2016)

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