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  1. No Access

    Article

    Key mediators of intracellular amino acids signaling to mTORC1 activation

    Mammalian target of rapamycin complex 1 (mTORC1) is activated by amino acids to promote cell growth via protein synthesis. Specifically, Ras-related guanosine triphosphatases (Rag GTPases) are activated by ami...

    Yehui Duan, Fengna Li, Kunrong Tan, Hongnan Liu, Yinghui Li, Yingying Liu… in Amino Acids (2015)

  2. No Access

    Article

    A review of the immunomodulatory role of dietary tryptophan in livestock and poultry

    Tryptophan, a nutritionally essential amino acid, is active in the regulation of immune responses in animals. The products of tryptophan metabolism, such as indoleamine 2,3-dioxygenase, kynurenine, quinolinic ...

    Miaomiao Bai, Hongnan Liu, Kang Xu, Abimbola Oladele Oso, **n Wu, Gang Liu… in Amino Acids (2017)

  3. No Access

    Article

    Structure and specificity of a permissive bacterial C-prenyltransferase

    Discovery and characterization of an unusually permissive C-prenyltransferase provides a biocatalytic route for generating novel prenylated compounds, including daptomycin derivatives with increased potency. ...

    Sherif I Elshahawi, Hongnan Cao, Khaled A Shaaban… in Nature Chemical Biology (2017)

  4. No Access

    Article

    UPLC-QTOF/MS-Based Metabolomics Reveals the Protective Mechanism of Hydrogen on Mice with Ischemic Stroke

    As a reductive gas, hydrogen plays an antioxidant role by selectively scavenging oxygen free radicals. It has been reported that hydrogen has protective effects against nerve damage caused by ischemia–reperfus...

    Lilin Chen, Yufan Chao, Pengchao Cheng, Na Li, Hongnan Zheng… in Neurochemical Research (2019)

  5. No Access

    Article

    Autophagy Dysfunction and mTOR Hyperactivation Is Involved in Surgery: Induced Behavioral Deficits in Aged C57BL/6J Mice

    Autophagy is crucial for cell survival, development, division, and homeostasis. The mammalian target of rapamycin (mTOR), which is the foremost negative controller of autophagy, plays a key role in many endoge...

    Yanhua Jiang, Yongjian Zhou, Hong Ma, Xuezhao Cao, Zhe Li… in Neurochemical Research (2020)

  6. No Access

    Article

    Advanced single-cell pooled CRISPR screening identifies C19orf53 required for cell proliferation based on mTORC1 regulators

    Multiplexed single-cell CRISPR screening has accelerated the systematic dissection of biological discoveries; however, the efficiency of CRISPR-based gene knockout has inherent limitations. Here, we present Do...

    Yulong Tang, Simeng Liao, Guang Liu, **a **ong, Hongnan Liu… in Cell Biology and Toxicology (2022)