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  1. No Access

    Article

    Advanced single-cell pooled CRISPR screening identifies C19orf53 required for cell proliferation based on mTORC1 regulators

    Multiplexed single-cell CRISPR screening has accelerated the systematic dissection of biological discoveries; however, the efficiency of CRISPR-based gene knockout has inherent limitations. Here, we present Do...

    Yulong Tang, Simeng Liao, Guang Liu, **a **ong, Hongnan Liu… in Cell Biology and Toxicology (2022)

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    Article

    A review of the immunomodulatory role of dietary tryptophan in livestock and poultry

    Tryptophan, a nutritionally essential amino acid, is active in the regulation of immune responses in animals. The products of tryptophan metabolism, such as indoleamine 2,3-dioxygenase, kynurenine, quinolinic ...

    Miaomiao Bai, Hongnan Liu, Kang Xu, Abimbola Oladele Oso, **n Wu, Gang Liu… in Amino Acids (2017)

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    Article

    Key mediators of intracellular amino acids signaling to mTORC1 activation

    Mammalian target of rapamycin complex 1 (mTORC1) is activated by amino acids to promote cell growth via protein synthesis. Specifically, Ras-related guanosine triphosphatases (Rag GTPases) are activated by ami...

    Yehui Duan, Fengna Li, Kunrong Tan, Hongnan Liu, Yinghui Li, Yingying Liu… in Amino Acids (2015)