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  1. Article

    Open Access

    A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair

    Inhibition of the Wnt antagonist sclerostin increases bone mass in patients with osteoporosis and in preclinical animal models. Here we show increased levels of the Wnt antagonist Dickkopf-1 (DKK-1) in animals...

    Monica Florio, Kannan Gunasekaran, Marina Stolina, **aodong Li… in Nature Communications (2016)

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    Article

    OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

    The tumour-necrosis-factor-family molecule osteoprotegerin ligand (OPGL; also known as TRANCE, RANKL and ODF) has been identified as a potential osteoclast differentiation factor and regulator of interactions ...

    Young-Yun Kong, Hiroki Yoshida, Ildiko Sarosi, Hong-Lin Tan, Emma Timms… in Nature (1999)