17 Result(s)
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Article
Haobin Zhao
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Article
Alternative splicing of medaka bcl6aa and its repression by Prdm1a and Prdm1b
Bcl6 and Prdm1 (Blimp1) are a pair of transcriptional factors that repressing each other in mammals. Prdm1 represses the expression of bcl6 by binding a cis-element of the bcl6 gene in mammals. The homologs of Bc...
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Open AccessEffects of Bacillus subtilis iturin A on HepG2 cells in vitro and vivo
Iturin A with cyclic peptide and fatty acid chain isolated from Bacillus subtilis fermentation shows a variety of biological activities. Among them, the anticancer activity attracted much attention. However, the ...
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Open AccessFundc1 is necessary for proper body axis formation during embryogenesis in zebrafish
FUN14 domain-containing protein 1 (FUNDC1) is a mitochondrial outer membrane protein which is responsible for hypoxia-induced mitophagy in mammalian cells. Knockdown of fundc1 is known to cause severe defects in ...
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Development of a paper-based method to detect Hg2+ in waste water using iturin from Bacillus subtilis
Colorimetric, fluorescence, and paper-based method were developed to measure the Hg2+ level in water using iturin A, a lipopeptide produced by Bacillus subtilis. Firstly, iturin was used to synthesize highly stab...
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Synthesis of silver nanoparticles and its contribution to the capability of Bacillus subtilis to deal with polluted waters
Bacillus subtilis widely exists in environment and shows a capability to deal with heavy metals and dyes in polluted waters by adsorption or biological oxidation and reduction. Little is known about the roles of ...
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Capability of iturin from Bacillus subtilis to inhibit Candida albicans in vitro and in vivo
Candida albicans is a fungal pathogen that is difficult to cure clinically. The current clinic C. albicans-inhibiting drugs are very harmful to humans. This study revealed the potential of iturin fractions from B...
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Origination, change, and modulation of geriatric disease-related gut microbiota during life
The age-related changes in the diversity and composition of the gut microbiota are well described in recent studies. These changes have been suggested to be influenced by age-associated weakening of the immune...
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Production of bioproducts by endophytic fungi: chemical ecology, biotechnological applications, bottlenecks, and solutions
Endophytes are microorganisms that colonize the interior of host plants without causing apparent disease. They have been widely studied for their ability to modulate relationships between plants and biotic/abi...
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Reversible switching between normal and thermally activated delayed fluorescence towards “smart” and single compound white-light luminescence via controllable conformational distribution
An organic compound exhibiting simultaneously reversible switch between its emission colors and luminescence mechanisms, possessing high contrast from deep blue normal fluorescence (NF) to yellow thermally act...
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Open AccessPotential of Bacillus subtilis lipopeptides in anti-cancer I: induction of apoptosis and paraptosis and inhibition of autophagy in K562 cells
The lipopeptide iturin from Bacillus subtilis has been found to have a potential inhibitory effect on breast cancer, alveolar adenocarcinoma, renal carcinoma, and colon adenocarcinoma. In this study, the potentia...
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Biological activity of lipopeptides from Bacillus
The lipopeptides of Bacillus are small metabolites that contain a cyclic structure formed by 7–10 amino acids (including 2–4 d-amino acids) and a beta-hydroxy fatty acid with 13–19 C atoms. These lipopeptides exh...
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Expression of mep50 in adult and embryos of medaka fish (Oryzias latipes)
Protein arginine methylation is important for gene regulation and biological processes. Methylosome protein 50 (Mep50) is identified as a partner of protein arginine methyltransferase 5 (Prmt5), a major enzyme...
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Expression, Crystallization and Preliminary X-ray Diffraction Analyses of Med-ORF10 in the Biosynthetic Pathway of an Antitumor Antibiotic Medermycin
Medermycin, as a prominent member of benzoisochromanequinones, possesses strong antitumor activity and is biosynthesized under the control of a 29-ORF-containing biosynthetic gene cluster. Most of ORFs in this...
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Germ cell-specific expression of dead end (dnd) in rare minnow (Gobiocypris rarus)
Rare minnow (Gobiocypris rarus) is an emerging model fish in China, and the development of its gonads is still elusive. Germ cell-specific genes are conserved in animals. Dead end (Dnd) was first documented as a ...
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Identification and expression profiles of prdm1 in medaka Oryzias latipes
Mouse Prdm1, also known as Blimp1, plays important roles in maturation and survival of lymphoid cells, as well as in organogenesis of muscle, limb, sensor organs and primordial germ cells. The homologues of mo...
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Medaka fish stem cells and their applications
Stem cells are present in develo** embryos and adult tissues of multicellular organisms. Owing to their unique features, stem cells provide excellent opportunities for experimental analyses of basic developm...
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Time course of foreign gene integration and expression in transgenic fish embryos
Using a nuclear transplantation approach, the integration and expression of the green fluorescent protein (GFP) gene in the embryogenesis of transgenic loach (Misgurnus anguillicaudatus Cantor) have been studied....
