12 Result(s)
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Article
Hao-**n Niu
Life Sciences
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Article
Chymase induces profibrotic response via transforming growth factor-β1/Smad activation in rat cardiac fibroblasts
Mast cell-derived chymase is implicated in myocardial fibrosis (MF), but the underlying mechanism of intracellular signaling remains unclear. Transforming growth factor-β1 (TGF-β1) is identified as the most im...
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Adaptation of the externally feeding bug Elasmucha necopinata (Hemiptera: Acanthosomatidae) to its fig host
Figs (Ficus) are keystone resources that maintain tropical biodiversity. Pollinators, non-pollinating fig wasps, and some insects that feed internally in syconia (the fruits of figs) synchronize their development...
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Notch signaling maintains proliferation and survival of the HL60 human promyelocytic leukemia cell line and promotes the phosphorylation of the Rb protein
The Notch signaling pathway has been implicated in the development of several leukemia and lymphoma. In order to investigate the relationship between Notch signaling and acute myeloid leukemia (AML), in this s...
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Development of an α-amylase reporter system for efficient screening of clones with highly expressed heterologous protein in Hansenula polymorpha
To check feasibility and effectiveness of the α-amylase reporter system, two vectors were designed and tested using hepatitis B virus surface antigen (HBsAg) and Homo sapiens granulocyte-macrophage colony stimula...
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Open AccessFTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis
The role of Fat Mass and Obesity-associated protein (FTO) and its substrate N6-methyladenosine (m6A) in mRNA processing and adipogenesis remains largely unknown. We show that FTO expression and m6A levels are inv...
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Open AccessResponse gene to complement 32 regulates the G2/M phase checkpoint during renal tubular epithelial cell repair
The aim of this study was to evaluate the influence of RGC-32 (response gene to complement 32) on cell cycle progression in renal tubular epithelial cell injury.
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Open Access5-methylcytosine promotes mRNA export — NSUN2 as the methyltransferase and ALYREF as an m5C reader
5-methylcytosine (m5C) is a post-transcriptional RNA modification identified in both stable and highly abundant tRNAs and rRNAs, and in mRNAs. However, its regulatory role in mRNA metabolism is still largely unkn...
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Comprehensive identification of peptides in tandem mass spectra using an efficient open search engine
Peptide identification in proteomics data is improved using an efficient open search engine.
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Open AccessEZH2-inhibitor DZNep enhances apoptosis of renal tubular epithelial cells in presence and absence of cisplatin
The enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase and induces the trimethylation of histone H3 lysine 27 (H3K27me3) in the promoter of many key genes; EZH2 acts as a transcriptional repress...
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Open AccessWolfberry genomes and the evolution of Lycium (Solanaceae)
Wolfberry Lycium, an economically important genus of the Solanaceae family, contains approximately 80 species and shows a fragmented distribution pattern among the Northern and Southern Hemispheres. Although seve...
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Suppressing ASPARTIC PROTEASE 1 prolongs photosynthesis and increases wheat grain weight
The elongation of photosynthesis, or functional staygreen, represents a feasible strategy to propel metabolite flux towards cereal kernels. However, achieving this goal remains a challenge in food crops. Here ...
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Open AccessIdentification of WUSCHEL-related homeobox gene and truncated small peptides in transformation efficiency improvement in Eucalyptus
The WUSCHEL-related Homeobox (WOX) genes, which encode plant-specific homeobox (HB) transcription factors, play crucial roles in regulating plant growth and development. However, the functions of WOX genes are li...
