36 Result(s)
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Article
Impact of near-infrared fluorescence imaging with indocyanine green on structural sequelae of anastomotic leakage after laparoscopic intersphincteric resection of malignant rectal tumors
Recent studies have indicated the potential benefit of intraoperative near-infrared fluorescence imaging (NIR-FI) with indocyanine green in reducing early anastomotic leakage in colorectal surgery. Nonetheless...
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Development of a performance rubric for transanal endoscopic rectal purse-string sutures
Placing a transanal endoscopic rectal purse-string suture (taEPS) is the crucial first component of transanal total mesorectal excision (taTME). However, no structured training is available to improve the proc...
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Article
Retraction Note: Effects of valsartan and amlodipine on home blood pressure and cardiovascular events in Japanese hypertensive patients: a subanalysis of the VART
The paper has been retracted due to concerns raised by the publishing institution regarding problems with management of conflicts of interest and with the reliability of the published data.
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Article
Expression of myeloperoxidase in acute myeloid leukemia blasts mirrors the distinct DNA methylation pattern involving the downregulation of DNA methyltransferase DNMT3B
Myeloperoxidase (MPO) has been associated with both a myeloid lineage commitment and favorable prognosis in patients with acute myeloid leukemia (AML). DNA methyltransferase inhibitors (decitabine and zeburali...
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Article
Randomized clinical trial comparing lightweight or heavyweight mesh for mesh plug repair of primary inguinal hernia
The aim of this study was to assess whether the application of a lightweight mesh for mesh plug repair (MPR) for primary inguinal hernia could reduce chronic pain or other symptoms associated with the insertio...
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Article
Erratum: Effects of valsartan and amlodipine on home blood pressure and cardiovascular events in Japanese hypertensive patients: a subanalysis of the VART
Correction to: Journal of Human Hypertension (2012) 26, 656–663; doi:10.1038/jhh.2011.91; published online 13 October 2011 The authors would like to correct the affiliation of Nobuo Shirahashi, who was include...
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Article
Effects of valsartan and amlodipine on home blood pressure and cardiovascular events in Japanese hypertensive patients: a subanalysis of the VART
The Valsartan Amlodipine Randomized Trial (VART) was performed to compare the beneficial effects of valsartan and amlodipine on cardiovascular events in Japanese hypertensive patients. In this subanalysis of t...
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Article
Erratum: Suppression of cell-cycle progression by Jun dimerization protein-2 (JDP2) involves downregulation of cyclin-A2
Correction to: Oncogene (2010) 29, 6245–6256; doi:10.1038/onc.2010.355; published online 30 August 2010. Since the publication of the above manuscript, the authors have identified an error in Supplementary Tab...
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Article
Immunohistochemical localization of notch signaling molecules in ameloblastomas
We examined Notch signaling molecules, Notch1 and Jagged1, in serial large cases of typical solid/multicystic ameloblastoma. In general, Notch positive staining products were frequently detected in the cytopla...
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Article
Open AccessLBH589, a deacetylase inhibitor, induces apoptosis in adult T-cell leukemia/lymphoma cells via activation of a novel RAIDD-caspase-2 pathway
Adult T-cell leukemia/lymphoma (ATLL), an aggressive neoplasm etiologically associated with human T-lymphotropic virus type-1 (HTLV-1), is resistant to treatment. In this study, we examined the effects of a ne...
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Open AccessSuppression of cell-cycle progression by Jun dimerization protein-2 (JDP2) involves downregulation of cyclin-A2
We report here a novel role for Jun dimerization protein-2 (JDP2) as a regulator of the progression of normal cells through the cell cycle. To determine the role of JDP2 in vivo, we generated Jdp2-knockout (Jdp2K...
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Article
Activation of p53 by Nutlin-3a, an antagonist of MDM2, induces apoptosis and cellular senescence in adult T-cell leukemia cells
It has been reported that the induction of cellular senescence through p53 activation is an effective strategy in tumor regression. Unfortunately, however, tumors including adult T-cell leukemia/lymphoma (ATL)...
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Transcellular relocation of tetrahydrobiopterin across Caco-2 cells: A model study of tetrahydrobiopterin absorption through epithelial cells of intestinal mucosa
Oral administration of tetrahydrobiopterin (BH4) has been known to be effective in treating BH4-deficient patients. It has long been established that BH4 is absorbed by the intestinal mucosa. However, the mechani...
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Article
Tetrahydrobiopterin in intestinal lumen: Its absorption and secretion in the small intestine and the elimination in the large intestine
In treating hereditary deficiency of tetrahydrobiopterin (BH4), supplementation with BH4 might be the ultimate choice of therapy. Oral administration of BH4 has been believed to be inefficient owing to poor absor...
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Article
Short- and midterm outcomes of laparoscopic surgery compared for 131 patients with rectal and rectosigmoid cancer
This study aimed to clarify and compare the short- and midterm surgical outcomes of laparoscopic surgery for rectal and rectosigmoid cancer.
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Article
The application of a new stapling device for open surgery (ContourTM Curved Cutter Stapler) in the laparoscopic resection of rectal cancer
Anastomotic leakage is a serious problem in the laparoscopic resection of rectal cancer. Although stapling devices and techniques for colorectal or coloanal anastomosis have been improved, laparoscopic anastom...
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Article
Percutaneous and laparoscopic approaches of radiofrequency ablation treatment for liver cancer
Background/Purpose. Radiofrequency ablation (RFA) and microwave coagulation therapy (MCT) have been gaining acceptance as a standard method in the management strategy of liver cancer, for...
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Article
Stereotactic radiofrequency ablation for sessile hypothalamic hamartoma with an image fusion technique
¶Background. Radiosurgery has been advocated as a primary treatment for hypothalamic hamartoma (HH), but it has a risk of damaging the surrounding structures and does not have an immediate effect for refractory e...
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Article
Laparoscopic surgery for stage I colorectal cancer
Background: This study analyzed the short- and long-term outcomes of laparoscopic surgery (LS) in patients with stage I colorectal cancer. Methods: A total of 130 patients with stage I co...
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Randomized controlled trial of laparoscopic versus open colectomy for advanced colorectal cancer
Background: After confirming a favorable outcome of laparoscopic surgery for early colorectal cancer, we conducted a randomized controlled trial to compare short-term outcomes of laparoscopic and open colectom...
