5 Result(s)
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Article
Giovanni Magistrelli
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Article
Open AccessDevelopment and characterization of NILK-2301, a novel CEACAM5xCD3 κλ bispecific antibody for immunotherapy of CEACAM5-expressing cancers
T-cell retargeting to eliminate CEACAM5-expressing cancer cells via CEACAM5xCD3 bispecific antibodies (BsAbs) showed limited clinical activity so far, mostly due to insufficient T-cell activation, dose-limitin...
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Open AccessExploiting light chains for the scalable generation and platform purification of native human bispecific IgG
Bispecific antibodies enable unique therapeutic approaches but it remains a challenge to produce them at the industrial scale, and the modifications introduced to achieve bispecificity often have an impact on ...
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GlycoDelete engineering of mammalian cells simplifies N-glycosylation of recombinant proteins
Engineered mammalian cells express glycoproteins with reduced glycan heterogeneity.
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OmpA targets dendritic cells, induces their maturation and delivers antigen into the MHC class I presentation pathway
We analyzed the interaction between a bacterial cell wall protein and dendritic cells (DCs). Outer membrane protein A from Klebsiella pneumoniae (kpOmpA) specifically bound to professional antigen presenting cell...
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Detection of a polymorphism in exon 8 of the human CD86 gene
