3 Result(s)
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Article
Gerhard Steger
Bioinformatics
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Article
Open AccessLost in folding space? Comparing four variants of the thermodynamic model for RNA secondary structure prediction
Many bioinformatics tools for RNA secondary structure analysis are based on a thermodynamic model of RNA folding. They predict a single, "optimal" structure by free energy minimization, they enumerate near-opt...
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Article
Open AccessConStruct: Improved construction of RNA consensus structures
Aligning homologous non-coding RNAs (ncRNAs) correctly in terms of sequence and structure is an unresolved problem, due to both mathematical complexity and imperfect scoring functions. High quality alignments,...
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Article
Open AccessAn enhanced RNA alignment benchmark for sequence alignment programs
The performance of alignment programs is traditionally tested on sets of protein sequences, of which a reference alignment is known. Conclusions drawn from such protein benchmarks do not necessarily hold for t...
