4 Result(s)
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Article
Open AccessConventional myelosuppressive chemotherapy for non-haematological malignancy disrupts the intestinal microbiome
The gut microbiota influences many aspects of host physiology, including immune regulation, and is predictive of outcomes in cancer patients. However, whether conventional myelosuppressive chemotherapy affects...
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Open AccessInvestigating potential transmission of antimicrobial resistance in an open-plan hospital ward: a cross-sectional metagenomic study of resistome dispersion in a lower middle-income setting
Antimicrobial resistance (AMR) represents a profound global health threat. Reducing AMR spread requires the identification of transmission pathways. The extent to which hospital wards represent a venue for sub...
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Article
Open AccessLung function and microbiota diversity in cystic fibrosis
Chronic infection and concomitant airway inflammation is the leading cause of morbidity and mortality for people living with cystic fibrosis (CF). Although chronic infection in CF is undeniably polymicrobial, ...
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Article
Open AccessDeriving accurate microbiota profiles from human samples with low bacterial content through post-sequencing processing of Illumina MiSeq data
The rapid expansion of 16S rRNA gene sequencing in challenging clinical contexts has resulted in a growing body of literature of variable quality. To a large extent, this is due to a failure to address spuriou...
