3,133 Result(s)

Article

The ubiquitin-like protein UBTD1 promotes colorectal cancer progression by stabilizing c-Myc to upregulate glycolysis

Dysfunction of the ubiquitin-proteasome system (UPS) is involved in the pathogenesis of various malignancies including colorectal cancer (CRC). Ubiquitin domain containing 1 (UBTD1), a ubiquitin-like protein, ...

Liqin Zhao, Nuoya Yu, Yujia Zhai, Yanan Yang, Yixuan Wang, Yue Yang… in Cell Death & Disease (2024)

Article

Age-related dysregulation of CXCL9/10 in monocytes is linked to impaired innate immune responses in a mouse model of Staphylococcus aureus osteomyelitis

Age-associated impairments in innate immunity are believed to be a causative factor responsible for severe pathogenesis of Staphylococcus aureus (S. aureus) infection in the bone tissue. However, the basis for ag...

Yihuang Lin, Mankai Yang, Chubin Cheng, Jichang Wu… in Cellular and Molecular Life Sciences (2024)

Article

TRAF6 promotes spinal microglial M1 polarization to aggravate neuropathic pain by activating the c-JUN/NF-kB signaling pathway

The neuropathic pain with complex networks of neuroinflammatory activation severely limits clinical therapeutic research. TNF receptor-associated factor 6 (TRAF6) is associated with multiple inflammatory disea...

Yu Zhao, Tiegang Li, Lichun Zhang, Jun Yang, Feng Zhao… in Cell Biology and Toxicology (2024)

Article

CD74 is a functional MIF receptor on activated CD4⁺ T cells

Next to its classical role in MHC II-mediated antigen presentation, CD74 was identified as a high-affinity receptor for macrophage migration inhibitory factor (MIF), a pleiotropic cytokine and major determinan...

Lin Zhang, Iris Woltering, Mathias Holzner… in Cellular and Molecular Life Sciences (2024)

Article

Dexmedetomidine and argon in combination against ferroptosis through tackling TXNIP-mediated oxidative stress in DCD porcine livers

Graft availability from donation after circulatory death (DCD) is significantly limited by ischaemia reperfusion (IR) injury. Effective strategies to mitigate IR injury in DCD grafts are essential to improve g...

Qian Chen, Jiashi Sun, **angfeng Liu, Zhigang Qin, Jieyu Li… in Cell Death Discovery (2024)

Article

LINC01133 promotes pancreatic ductal adenocarcinoma epithelial–mesenchymal transition mediated by SPP1 through binding to Arp3

Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with limited treatment methods. Long non-coding RNAs (lncRNAs) have been found involved in tumorigenic and progression. The present study revealed th...

Yefan Yang, Yuxi Gong, Ying Ding, Shuning Sun, Rumeng Bai… in Cell Death & Disease (2024)

Article

SETD8 inhibits apoptosis and ferroptosis of Ewing’s sarcoma through YBX1/RAC3 axis

Ewing’s sarcoma (ES) represents a rare yet exceedingly aggressive neoplasm that poses a significant health risk to the pediatric and adolescent population. The clinical outcomes for individuals with relapsed o...

Huimou Chen, **g Hu, **lin **ong, Hongling Chen, Qiaofang Liao… in Cell Death & Disease (2024)

Article

Publisher Correction: Restrained Mitf-associated autophagy by Mulberroside A ameliorates osteoclastogenesis and counteracts OVX-Induced osteoporosis in mice

Hong Xue, Zhenhua Feng, Putao Yuan, Li Qiao, Qiliang Lou… in Cell Death Discovery (2024)

Article

IL-27 disturbs lipid metabolism and restrains mitochondrial activity to inhibit γδ T17 cell-mediated skin inflammation

IL-17+ γδ T cells (γδ T17) are kick-starters of inflammation due to their strict immunosurveillance of xenobiotics or cellular damages and rapid response to pro-inflammatory stimulators. IL-27 is a well-recogn...

Mingyue Zhang, Dehai Li, **g Zhu, Xue **a, Hua Zhang, Jie Wu… in Cell Death & Disease (2024)

Article

The Toxoplasma secreted effector TgWIP modulates dendritic cell motility by activating host tyrosine phosphatases Shp1 and Shp2

The obligate intracellular parasite Toxoplasma gondii causes life-threatening toxoplasmosis to immunocompromised individuals. The pathogenesis of Toxoplasma relies on its swift dissemination to the central nervou...

Pavel Morales, Abbigale J. Brown… in Cellular and Molecular Life Sciences (2024)

Article

The combination of temozolomide and perifosine synergistically inhibit glioblastoma by impeding DNA repair and inducing apoptosis

Temozolomide (TMZ) is widely utilized as the primary chemotherapeutic intervention for glioblastoma. However, the clinical use of TMZ is limited by its various side effects and resistance to chemotherapy. The ...

Wenpeng Zhao, Liwei Zhou, Wentao Zhao, Huiying Yang, Zhenwei Lu… in Cell Death Discovery (2024)

Article

Human cytomegalovirus infection impairs neural differentiation via repressing sterol regulatory element binding protein 2-mediated cholesterol biosynthesis

Congenital human cytomegalovirus (HCMV) infection is a major cause of abnormalities and disorders in the central nervous system (CNS) and/or the peripheral nervous system (PNS). However, the complete pathogene...

Jianming Li, **gxuan Sun, Mingyi Xu, Lei Yang… in Cellular and Molecular Life Sciences (2024)

Article

Origin recognition complex 6 overexpression promotes growth of glioma cells

The discovery of novel oncotargets for glioma is of immense significance. We here explored the expression patterns, biological functions, and underlying mechanisms associated with ORC6 (origin recognition comp...

Wen-lei Yang, Wei-feng Zhang, Yin Wang, Yue Lou, Yu Cai, Jun Zhu in Cell Death & Disease (2024)

Article

Publisher Correction: Mechanisms underlying the interactions and adaptability of nitrogen removal microorganisms in freshwater sediments

Dandan Zhang, Huang Yu, **aoli Yu, Yuchun Yang, Cheng Wang… in Advanced Biotechnology (2024)

Article

Protein SUMOylation promotes cAMP-independent EPAC1 activation

Protein SUMOylation is a prevalent stress-response posttranslational modification crucial for maintaining cellular homeostasis. Herein, we report that protein SUMOylation modulates cellular signaling mediated ...

Wenli Yang, Fang C. Mei, Wei Lin, Mark A. White… in Cellular and Molecular Life Sciences (2024)

Article

Advances in research on immunocyte iron metabolism, ferroptosis, and their regulatory roles in autoimmune and autoinflammatory diseases

Autoimmune diseases commonly affect various systems, but their etiology and pathogenesis remain unclear. Currently, increasing research has highlighted the role of ferroptosis in immune regulation, with immune...

Liuting Zeng, Kailin Yang, Ganpeng Yu, Wensa Hao, **aofei Zhu… in Cell Death & Disease (2024)

Article

Correction: Correlations of FCGR2A 131R/H and FCGR3A 158V/F Polymorphisms with the Susceptibility of Peri-implantitis in Chinese Han Population

Peng Li, Bingzhuo Chen, Liang Zhao, Feng Yang, Zhu Zhang… in Molecular Biotechnology (2024)

Article

Publisher Correction: LINC317.5 as a novel biomarker for hypertriglyceridemia in abnormal glucose metabolism

Yixue Yang, Mengzi Sun, Shoumeng Yan, Nan Yao, **aotong Li… in Cell Death Discovery (2024)

Article

Correction: Dysfunction of ATG7-dependent autophagy dysregulates the antioxidant response and contributes to oxidative stress-induced biological impairments in human epidermal melanocytes

Zhuhui Qiao, Zhongyi Xu, Qing **ao, Yiwen Yang, Jiayi Ying… in Cell Death Discovery (2024)

Article

Zinc oxide nanoparticles induces cell death and consequently leading to incomplete neural tube closure through oxidative stress during embryogenesis

The implementation of Zinc oxide nanoparticles (ZnO NPs) raises concerns regarding their potential toxic effects on human health. Although more and more researches have confirmed the toxic effects of ZnO NPs, ...

Yu Yan, Wenyi Huang, **aoting Lu, **anxian Chen, Yingyi Shan… in Cell Biology and Toxicology (2024)