17 Result(s)
within
English
Biomedicine
Biomedicine, general
Gareth J. Morgan
Article
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Article
Open AccessAnthropometric traits and risk of multiple myeloma: differences by race, sex and diagnostic clinical features
Obesity is an established modifiable risk factor for multiple myeloma (MM). However, associations of obesity and MM risk in Black populations, for whom obesity and MM are more common, is less clear.
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Open AccessA pooled analysis of outcomes according to cytogenetic abnormalities in patients receiving ixazomib- vs placebo-based therapy for multiple myeloma
Some cytogenetic abnormalities (CAs) are associated with poorer prognosis in multiple myeloma (MM); proteasome inhibitors appear to benefit patients with high-risk CAs. We evaluated 2247 MM patients from the T...
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Open AccessStructural variants shape the genomic landscape and clinical outcome of multiple myeloma
Deciphering genomic architecture is key to identifying novel disease drivers and understanding the mechanisms underlying myeloma initiation and progression. In this work, using the CoMMpass dataset, we show th...
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Open AccessIxazomib with cyclophosphamide and dexamethasone in relapsed or refractory myeloma: MUKeight phase II randomised controlled trial results
The all-oral combination of ixazomib, cyclophosphamide, and dexamethasone (ICD) is well tolerated and effective in newly diagnosed and relapsed multiple myeloma (MM). We carried out MUKeight, a randomised, con...
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Open AccessInternational Myeloma Working Group risk stratification model for smoldering multiple myeloma (SMM)
Smoldering multiple myeloma (SMM) is an asymptomatic precursor state of multiple myeloma (MM). Recently, MM was redefined to include biomarkers predicting a high risk of progression from SMM, thus necessitatin...
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Open AccessAn enhanced genetic model of relapsed IGH-translocated multiple myeloma evolutionary dynamics
Most patients with multiple myeloma (MM) die from progressive disease after relapse. To advance our understanding of MM evolution mechanisms, we performed whole-genome sequencing of 80 IGH-translocated tumour-nor...
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Open AccessAn acquired high-risk chromosome instability phenotype in multiple myeloma: Jum** 1q Syndrome
Patients with multiple myeloma (MM) accumulate adverse copy number aberrations (CNAs), gains of 1q21, and 17p deletions during disease progression. A subset of these patients develops heightened 1q12 pericentr...
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Open AccessGenetic correlation between multiple myeloma and chronic lymphocytic leukaemia provides evidence for shared aetiology
The clustering of different types of B-cell malignancies in families raises the possibility of shared aetiology. To examine this, we performed cross-trait linkage disequilibrium (LD)-score regression of multip...
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Open AccessMAFb protein confers intrinsic resistance to proteasome inhibitors in multiple myeloma
Multiple myeloma (MM) patients with t(14;20) have a poor prognosis and their outcome has not improved following the introduction of bortezomib (Bzb). The mechanism underlying the resistance to proteasome inhib...
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Open AccessActive multiple myeloma suppresses and typically eliminates coexisting MGUS
Myeloma is consistently preceded by premalignant monoclonal gammopathy of undetermined significance (MGUS). In >5% of MGUS patients there is a second MGUS clone (biclonal gammopathy of undetermined significanc...
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Evolutionary biology of high-risk multiple myeloma
Treatment of myeloma has developed rapidly over the past two decades with the advent of proteasome inhibitors and immunomodulatory agents. Despite their dramat...
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Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk
Richard Houlston and colleagues report a genome-wide association study of multiple myeloma and identify four loci associated with susceptibility to this malignancy.
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The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma
Richard Houlston, Kari Hemminki and colleagues report a meta-analysis of genome-wide association studies of multiple myeloma and identify a variant in the CCDN1 gene that influences risk for develo** a specific...
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The genetic architecture of multiple myeloma
The initiation of myeloma is mediated by the interaction of environmental factors and inherited genetic events that, when combined with the normal physiologica...
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Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk
Richard Houlston, Gareth Morgan, Kari Hemminki and colleagues report the results of a genome-wide association study of multiple myeloma. They identify two regions influencing susceptibility to this hematologic...
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Targeting Bone as a Therapy for Myeloma
Myeloma bone disease (BD) not only impairs quality of life, but is also associated with impaired survival. Studies of the biology underlying BD support the notion that the increased osteoclastogenesis and supp...
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Tobacco and Alcohol Consumption and the Risk of Non-Hodgkin Lymphoma
Objective: The aim was to test whether non-Hodgkin lymphoma (NHL) is associated with smoking or alcohol.
