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Article

A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis

Activin receptor-like kinase 1 (ALK1, encoded by the gene ACVRL1) is a type I BMP/TGF-β receptor that mediates signalling in endothelial cells via phosphorylation of SMAD1/5/8. During angiogenesis, sprouting endo...

Georgina Kerr, Helen Sheldon, Apirat Chaikuad, Ivan Alfano, Frank von Delft… in Angiogenesis (2015)