12 Result(s)
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Article
Francisco X Real
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessNFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and restrains PDAC initiation
Pancreatic acinar cells rely on PTF1 and other transcription factors to deploy their transcriptional program. We identify NFIC as a NR5A2 interactor and regulator of acinar differentiation. NFIC binding sites ...
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Open AccessAn integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer
The molecular landscape in non-muscle-invasive bladder cancer (NMIBC) is characterized by large biological heterogeneity with variable clinical outcomes. Here, we perform an integrative multi-omics analysis of...
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Open AccessPublisher Correction: Pancreatic duct ligation reduces premalignant pancreatic lesions in a Kras model of pancreatic adenocarcinoma in mice
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Open AccessPancreatic duct ligation reduces premalignant pancreatic lesions in a Kras model of pancreatic adenocarcinoma in mice
Pancreatic duct ligation (PDL) in the murine model has been described as an exocrine pancreatic atrophy-inducing procedure. However, its influence has scarcely been described on premalignant lesions. This stud...
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Open AccessUrothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity
Understanding urothelial stem cell biology and differentiation has been limited by the lack of methods for their unlimited propagation. Here, we establish mouse urothelial organoids that can be maintained unin...
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Open AccessGenome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer
In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to d...
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Transcriptional regulation by NR5A2 links differentiation and inflammation in the pancreas
In mouse pancreas cells with only one copy of the Nr5a2 gene, the orphan nuclear receptor NR5A2 undergoes a marked transcriptional shift from differentiation-specific to inflammatory genes, which results in an ep...
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Erratum: A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns
Nature 538, 378–382 (2016); doi:10.1038/nature19823 In this Letter, owing to a typesetter error the ‘received date’ was incorrectly shown as ‘8 August 2015’ instead of ‘27 November 2015’ in both the print and ...
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A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns
Pancreatic cancer is not caused by a specific series of genetic alterations that occur sequentially but by one, or few, catastrophic events that result in simultaneous oncogenic genetic rearrangements, giving ...
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Open AccessFemale chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome
To investigate large structural clonal mosaicism of chromosome X, we analysed the SNP microarray intensity data of 38,303 women from cancer genome-wide association studies (20,878 cases and 17,425 controls) an...
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Open AccessBPTF is required for c-MYC transcriptional activity and in vivo tumorigenesis
c-MYC oncogene is deregulated in most human tumours. Histone marks associated with transcriptionally active genes define high-affinity c-MYC targets. The mechanisms involved in their recognition by c-MYC are u...
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Klf4 and Klf5 differentially inhibit mesoderm and endoderm differentiation in embryonic stem cells
Krüppel-like factors (Klf) 4 and 5 are two closely related members of the Klf family, known to play key roles in cell cycle regulation, somatic cell reprogramming and pluripotency. Here we focus on the functio...
