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  1. Article

    Open Access

    Synergism between IL7R and CXCR4 drives BCR-ABL induced transformation in Philadelphia chromosome-positive acute lymphoblastic leukemia

    Ph+ acute lymphoblastic leukemia (ALL) is characterized by the expression of an oncogenic fusion kinase termed BCR-ABL1. Here, we show that interleukin 7 receptor (IL7R) interacts with the chemokine receptor CXCR...

    Hend Abdelrasoul, Anila Vadakumchery, Markus Werner, Lennart Lenk… in Nature Communications (2020)

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  2. Article

    Open Access

    Monitoring the dynamics of clonal tumour evolution in vivo using secreted luciferases

    Tumours are heterogeneous cell populations that undergo clonal evolution during tumour progression, metastasis and response to therapy. Short hairpin RNAs (shRNAs) generate stable loss-of-function phenotypes a...

    Joël P. Charles, Jeannette Fuchs, Mirjam Hefter… in Nature Communications (2014)

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