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  1. Article

    Open Access

    Pharmacological inhibition of MyD88 homodimerization counteracts renal ischemia reperfusion-induced progressive renal injury in vivo and in vitro

    The activation of innate immunity via myeloid differentiation factor 88 (MyD88) contributes to ischemia reperfusion (I/R) induced acute kidney injury (AKI) and chronic kidney injury. However, since there have ...

    Li-Min Zhang, Jian-Hua Liu, Cheng-Biao Xue, Ming-Qiang Li, Shuai **ng… in Scientific Reports (2016)

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    Article

    Pharmacopore hypothesis generation of BACE-1 inhibitors and pharmacophore-driven identification of potent multi-target neuroprotective agents

    A three dimensional (3D) pharmacophore model of Beta-site APP cleaving enzymes 1 (BACE-1) inhibitors with strong capability of activity prediction was generated for pharmacophore-driven identification of poten...

    Wen-Ting Zhang, Feng-Chao Jiang, Dong Liu, Guang Du in Medicinal Chemistry Research (2012)