4 Result(s)
within
Science, Humanities and Social Sciences, multidisciplinary
Science, Humanities and Social Sciences, multidisciplinary
Fabiola Cecchi
Article
-
Article
Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS
Hypoactive BRAF mutants bind more tightly than wild type to the upstream regulator RAS, thus amplifying to amplify ERK signalling; tumours expressing these mutants require coexistent mechanisms for RAS activat...
-
Article
Open AccessTargeted multiplex proteomics for molecular prescreening and biomarker discovery in metastatic colorectal cancer
Protein biomarkers are widely used in cancer diagnosis, prognosis, and prediction of treatment response. Here we introduce the use of targeted multiplex proteomics (TMP) as a tool to simultaneously measure a p...
-
Article
Open AccessThe addition of FAIMS increases targeted proteomics sensitivity from FFPE tumor biopsies
Mass spectrometry-based targeted proteomics allows objective protein quantitation of clinical biomarkers from a single section of formalin-fixed, paraffin-embedded (FFPE) tumor tissue biopsies. We combined hig...
-
Article
Open AccessHER2 quantitative continuous scoring for accurate patient selection in HER2 negative trastuzumab deruxtecan treated breast cancer
Many targeted cancer therapies rely on biomarkers assessed by scoring of immunohistochemically (IHC)-stained tissue, which is subjective, semiquantitative, and does not account for expression heterogeneity. We...
