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  1. Article

    Open Access

    Structure-based drug discovery of a corticotropin-releasing hormone receptor 1 antagonist using an X-ray free-electron laser

    Thus far, attempts to develop drugs that target corticotropin-releasing hormone receptor 1 (CRF1R), a drug target in stress-related therapy, have been unsuccessful. Studies have focused on using high-resolution G...

    Hoyoung Kim, Taehyun Lim, Go Eun Ha, Jee-Young Lee… in Experimental & Molecular Medicine (2023)

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    Article

    GABA tone regulation and its cognitive functions in the brain

    γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter released at GABAergic synapses, mediating fast-acting phasic inhibition. Emerging lines of evidence unequivocally indicate that a small amoun...

    Wuhyun Koh, Hankyul Kwak, Eunji Cheong, C. Justin Lee in Nature Reviews Neuroscience (2023)

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    Article

    Three-dimensional brain-like microenvironments facilitate the direct reprogramming of fibroblasts into therapeutic neurons

    Biophysical cues can improve the direct reprogramming of fibroblasts into neurons that can be used for therapeutic purposes. However, the effects of a three-dimensional (3D) environment on direct neuronal repr...

    Yoonhee **, Jung Seung Lee, ** Kim, Sung** Min… in Nature Biomedical Engineering (2018)