29 Result(s)

Article

Exploring ALK fusion in colorectal cancer: a case series and comprehensive analysis

Anaplastic lymphoma kinase (ALK) fusion-positive colorectal cancer (CRC) is a rare and chemotherapy-refractory subtype that lacks established and effective treatment strategies. Additionally, the efficacy and ...

Zi-**g Li, William Pat Fong, Dong-Sheng Zhang, Hui-Yan Luo… in npj Precision Oncology (2024)

Article

XELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer: a multicenter, open-label, randomized, controlled, phase 3 trial

Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer (mCRC), but the prognosis remains poor. This phase 3 trial ...

Qiu-Zhong Pan, **g-**g Zhao, Liang Liu… in Signal Transduction and Targeted Therapy (2024)

Article

Correction: c-Myc-driven glycolysis polarizes functional regulatory B cells that trigger pathogenic inflammatory responses

Xu-Yan Wang, Yuan Wei, Bo Hu, Yuan Liao… in Signal Transduction and Targeted Therapy (2024)

Article

Alpha5 nicotine acetylcholine receptor subunit promotes intrahepatic cholangiocarcinoma metastasis

Neurotransmitter-initiated signaling pathway were reported to play an important role in regulating the malignant phenotype of tumor cells. Cancer cells could exhibit a “neural addiction” property and build up ...

Yan Fu, Keyu Shen, Hao Wang, Shun Wang… in Signal Transduction and Targeted Therapy (2024)

Article

Single-cell RNA sequencing of a new transgenic t(8;21) preleukemia mouse model reveals regulatory networks promoting leukemic transformation

T(8;21)(q22;q22), which generates the AML1-ETO fusion oncoprotein, is a common chromosomal abnormality in acute myeloid leukemia (AML) patients. Despite having favorable prognosis, 40% of patients will relapse...

Ming Yan, Mengdan Liu, Amanda G. Davis, Samuel A. Stoner, Dong-Er Zhang in Leukemia (2024)

Article

Neoadjuvant nivolumab with or without platinum-doublet chemotherapy based on PD-L1 expression in resectable NSCLC (CTONG1804): a multicenter open-label phase II study

This prospective multicenter phase II study evaluated the clinical efficacy of neoadjuvant nivolumab-exclusive (N) and nivolumab–chemotherapy (N/C) combinations based on PD-L1 expression. Eligible patients exh...

Si-Yang Liu, Song Dong, Xue-Ning Yang… in Signal Transduction and Targeted Therapy (2023)

Article

Non-small cell lung cancers (NSCLCs) oncolysis using coxsackievirus B5 and synergistic DNA-damage response inhibitors

With the continuous in-depth study of the interaction mechanism between viruses and hosts, the virus has become a promising tool in cancer treatment. In fact, many oncolytic viruses with selectivity and effect...

Bopei Cui, Lifang Song, Qian Wang, Kelei Li… in Signal Transduction and Targeted Therapy (2023)

Article

Cryo-EM structure of the nucleocapsid-like assembly of respiratory syncytial virus

Respiratory syncytial virus (RSV) is a nonsegmented, negative strand RNA virus that has caused severe lower respiratory tract infections of high mortality rates in infants and the elderly, yet no effective vac...

Yan Wang, Chong Zhang, Yongbo Luo, **aobin Ling… in Signal Transduction and Targeted Therapy (2023)

Article

High-density lipoprotein regulates angiogenesis by long non-coding RNA HDRACA

Normal high-density lipoprotein (nHDL) can induce angiogenesis in healthy individuals. However, HDL from patients with coronary artery disease undergoes various modifications, becomes dysfunctional (dHDL), and...

Zhi-Wei Mo, Yue-Ming Peng, Yi-**n Zhang, Yan Li… in Signal Transduction and Targeted Therapy (2023)

Article

Induction immune-checkpoint inhibitors for resectable oncogene-mutant NSCLC: A multicenter pooled analysis

Despite limited efficacy of immunotherapy for advanced non-small-cell lung cancer (NSCLC) with driver mutations, whether neoadjuvant immunotherapy could be clinically valuable in those patients warrants furthe...

Chao Zhang, Hua-Fei Chen, Shi Yan, Lin Wu, Li-Xu Yan… in npj Precision Oncology (2022)

Article

Tobacco carcinogen induces tryptophan metabolism and immune suppression via induction of indoleamine 2,3-dioxygenase 1

Indoleamine 2,3-dioxygenase 1 (IDO1), the enzyme that catabolizes tryptophan (Trp) metabolism to promote regulatory T cells (Tregs) and suppress CD8⁺ T cells, is regulated by several intrinsic signaling pathways....

Fan Liang, Gui-Zhen Wang, Yan Wang… in Signal Transduction and Targeted Therapy (2022)

Article

Natural killer cell homing and trafficking in tissues and tumors: from biology to application

Natural killer (NK) cells, a subgroup of innate lymphoid cells, act as the first line of defense against cancer. Although some evidence shows that NK cells can develop in secondary lymphoid tissues, NK cells d...

Guang he Ran, Yu qing Lin, Lei Tian, Tao Zhang… in Signal Transduction and Targeted Therapy (2022)

Article

c-Myc-driven glycolysis polarizes functional regulatory B cells that trigger pathogenic inflammatory responses

B cells secreting IL-10 functionally are recognized as functional regulatory B (B_reg) cells; however, direct evidence concerning the phenotype, regulation, and functional and clinical relevance of IL-10-secreting...

Xu-Yan Wang, Yuan Wei, Bo Hu, Yuan Liao… in Signal Transduction and Targeted Therapy (2022)

Article

Cannabis suppresses antitumor immunity by inhibiting JAK/STAT signaling in T cells through CNR2

The combination of immune checkpoint blockade (ICB) with chemotherapy significantly improves clinical benefit of cancer treatment. Since chemotherapy is often associated with adverse events, concomitant treatm...

**nxin **ong, Siyu Chen, Jianfei Shen, Hua You… in Signal Transduction and Targeted Therapy (2022)

Article

Acute myeloid leukemia cell membrane-coated nanoparticles for cancer vaccination immunotherapy

Cancer vaccines are promising treatments to prevent relapse after chemotherapy in acute myeloid leukemia (AML) patients, particularly for those who cannot tolerate intensive consolidation therapies. Here, we r...

Daniel T. Johnson, Jiarong Zhou, Ashley V. Kroll, Ronnie H. Fang, Ming Yan… in Leukemia (2022)

Article

Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion

Ischemic stroke represents a significant danger to human beings, especially the elderly. Interventions are only available to remove the clot, and the mechanism of neuronal death during ischemic stroke is still...

Qing-zhang Tuo, Yu Liu, … in Signal Transduction and Targeted Therapy (2022)

Article

Fis1 phosphorylation by Met promotes mitochondrial fission and hepatocellular carcinoma metastasis

Met tyrosine kinase, a receptor for a hepatocyte growth factor (HGF), plays a critical role in tumor growth, metastasis, and drug resistance. Mitochondria are highly dynamic and undergo fission and fusion to m...

Yan Yu, **ao-Dan Peng, **ao-Jun Qian… in Signal Transduction and Targeted Therapy (2021)

Article

The way of SARS-CoV-2 vaccine development: success and challenges

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19). To halt the pandemic, multiple SARS-CoV-2 vaccines have been developed and several ha...

Yetian Dong, Tong Dai, Bin Wang, Lei Zhang… in Signal Transduction and Targeted Therapy (2021)

Article

Genomic characterization and outcome evaluation of kinome fusions in lung cancer revealed novel druggable fusions

Kinase fusions represent an important type of somatic alterations that promote oncogenesis and serve as diagnostic markers in lung cancer. We aimed to identify the landscape of clinically relevant kinase fusio...

Binghao Li, Hao Qu, **g Zhang, Weibo Pan, Meng Liu, **aobo Yan… in npj Precision Oncology (2021)