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  1. Article

    Open Access

    TRIB3 promotes the progression of renal cell carcinoma by upregulating the lipid droplet-associated protein PLIN2

    Abnormal lipid metabolism and lipid accumulation are characteristic hallmarks of renal cell carcinoma (RCC). While there is prior evidence closely linking such lipid accumulation within RCC cells and consequen...

    Jun Li, Qian Zhang, Yupeng Guan, Dingzhun Liao, Huikun Chen in Cell Death & Disease (2024)

  2. Article

    Open Access

    Circular RNA circVAMP3 promotes aerobic glycolysis and proliferation by regulating LDHA in renal cell carcinoma

    Metabolic dysfunction is seen in cancer cells where increased glycolysis provides energy for growth. Circular RNAs (circRNAs) are thought to assist in glucose metabolism and the switch to glycolysis. Through s...

    Jun Li, Qian Zhang, Yupeng Guan, Dingzhun Liao, Donggen Jiang in Cell Death & Disease (2022)

  3. Article

    Open Access

    Overexpression of PFKFB3 promotes cell glycolysis and proliferation in renal cell carcinoma

    Cancer cells prefer utilizing aerobic glycolysis in order to exacerbate tumor mass and maintain un-regulated proliferative rates. As a key glycolytic activator, phosphofructo-2-kinase/fructose-2,6-bisphosphata...

    Jun Li, Shiqiang Zhang, Dingzhun Liao, Qian Zhang, Chujie Chen, **angwei Yang in BMC Cancer (2022)