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  1. Article

    Open Access

    Brain age as a biomarker for pathological versus healthy ageing – a REMEMBER study

    This study aimed to evaluate the potential clinical value of a new brain age prediction model as a single interpretable variable representing the condition of our brain. Among many clinical use cases, brain ag...

    Mandy M.J. Wittens, Stijn Denissen, Diana M. Sima in Alzheimer's Research & Therapy (2024)

  2. Article

    Open Access

    A deep learning model for brain segmentation across pediatric and adult populations

    Automated quantification of brain tissues on MR images has greatly contributed to the diagnosis and follow-up of neurological pathologies across various life stages. However, existing solutions are specificall...

    Jaime Simarro, Maria Ines Meyer, Simon Van Eyndhoven, Thanh Vân Phan in Scientific Reports (2024)

  3. Article

    Open Access

    Towards validation in clinical routine: a comparative analysis of visual MTA ratings versus the automated ratio between inferior lateral ventricle and hippocampal volumes in Alzheimer’s disease diagnosis

    To assess the performance of the inferior lateral ventricle (ILV) to hippocampal (Hip) volume ratio on brain MRI, for Alzheimer’s disease (AD) diagnostics, comparing it to individual automated ILV and hippocam...

    Mandy M. J. Wittens, Gert-Jan Allemeersch, Diana M. Sima in Neuroradiology (2024)

  4. Article

    Open Access

    Semi-automated brain tumor segmentation on multi-parametric MRI using regularized non-negative matrix factorization

    Segmentation of gliomas in multi-parametric (MP-)MR images is challenging due to their heterogeneous nature in terms of size, appearance and location. Manual tumor segmentation is a time-consuming task and cli...

    Nicolas Sauwen, Marjan Acou, Diana M. Sima, Jelle Veraart in BMC Medical Imaging (2017)

  5. No Access

    Article

    Regularized Total Least Squares Based on Quadratic Eigenvalue Problem Solvers

    This paper presents a new computational approach for solving the Regularized Total Least Squares problem. The problem is formulated by adding a quadratic constraint to the Total Least Square minimization prob...

    Diana M. Sima, Sabine Van Huffel, Gene H. Golub in BIT Numerical Mathematics (2004)