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  1. Article

    Open Access

    DNMT1-targeting remodeling global DNA hypomethylation for enhanced tumor suppression and circumvented toxicity in oral squamous cell carcinoma

    The faithful maintenance of DNA methylation homeostasis indispensably requires DNA methyltransferase 1 (DNMT1) in cancer progression. We previously identified DNMT1 as a potential candidate target for oral squ...

    Yangfan Liu, Yu Sun, ** Yang, Deyang Wu, Shuang Yu, Junjiang Liu… in Molecular Cancer (2024)

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  2. Article

    Open Access

    Down-regulation of DNA key protein-FEN1 inhibits OSCC growth by affecting immunosuppressive phenotypes via IFN-γ/JAK/STAT-1

    Oral squamous cell carcinoma (OSCC) escape from the immune system is mediated through several immunosuppressive phenotypes that are critical to the initiation and progression of tumors. As a hallmark of cancer...

    Shimeng Wang, **angjian Wang, Jun Sun, ** Yang… in International Journal of Oral Science (2023)

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  3. Article

    Open Access

    TGF-β signaling in the tumor metabolic microenvironment and targeted therapies

    Transforming growth factor-β (TGF-β) signaling has a paradoxical role in cancer progression, and it acts as a tumor suppressor in the early stages but a tumor promoter in the late stages of cancer. Once cancer...

    Xueke Shi, ** Yang, Shuzhi Deng, Hongdan Xu, Deyang Wu… in Journal of Hematology & Oncology (2022)

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