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Open AccessTransient PP2A inhibition alleviates normal tissue stem cell susceptibility to cell death during radiotherapy
Unintended outcomes of cancer therapy include ionizing radiation (IR)-induced stem cell depletion, diminished regenerative capacity, and accelerated aging. Stem cells exhibit attenuated DNA damage response (DD...
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Open AccessMolecular and epigenetic regulatory mechanisms of normal stem cell radiosensitivity
Ionizing radiation (IR) therapy is a major cancer treatment modality and an indispensable auxiliary treatment for primary and metastatic cancers, but invariably results in debilitating organ dysfunctions. IR-i...