-
Article
Assignment of 1H, 13C and 15N resonances of the reduced human IgG1 CH3 domain
Here we report the NMR resonance assignments for the reduced form of human IgG1 CH3 domain, a 26 kDa dimer in solution (residues 341–447). The assignments have been deposited in the BioMagResBank with a BMRB acce...
-
Article
Assignment of backbone 1H, 13C and 15N resonances of human IgG1 Fc (51.4 kDa)
Here we report the NMR resonance assignments for the Fc region of human IgG1 expressed in E. coli, a 51.4 kDa dimer in solution (residues 221–447). The assignments have been deposited in the BioMagResBank with a ...
-
Article
Elucidation of Degradants in Acidic Peak of Cation Exchange Chromatography in an IgG1 Monoclonal Antibody Formed on Long-Term Storage in a Liquid Formulation
An IgG1 therapeutic monoclonal antibody showed an increase in acidic or pre-peak by cation exchange chromatography (CEX) at elevated temperatures, though stable at 2–8°C long-term storage in a liquid formulati...
-
Article
Designing optimal number of receiving traces based on simulation model
Currently, the selection of receiving traces in geometry design is mostly based on the horizontal layered medium hypothesis, which is unable to meet survey requirements in a complex area. This paper estimates ...
-
Article
Self-assembled ZnCo2O4 micro-urchins as high-performance electrode materials for energy storage device
Self-assembled ZnCo2O4 micro-urchins grown on nickel foam were synthesized by a simple hydrothermal method. The ZnCo2O4 micro-urchin exhibited high capacitance (1.043 C cm−2 at 1 mA cm−2) and excellent cycle stab...
-
Article
A hybrid representation-based simile component extraction
Simile, a special type of metaphor, can help people to express their ideas more clearly. Simile component extraction is to extract tenors and vehicles from sentences. This task has a realistic significance sin...
-
Article
Open AccessComparison of bipolar plasmakinetic resection of prostate versus photoselective vaporization of prostate by a three year retrospective observational study
Comprehensive evaluation of photoselective vaporization of the prostate (PVP) versus plasmakinetic resection of the prostate (PKRP) in treating benign prostatic hyperplasia (BPH) is inadequate. This single-cen...
-
Article
Composition and processing of direct-quench hot rolled steels with ultrahigh strength exceeding GPa
The design of high-strength steel has long been discussed in the field of metal structural materials. To further increase the strength of common high-strength steel and further decrease the cost for production...
-
Article
Synthesis of pyrazole-4-carboxamides as potential fungicide candidates
A series of novel pyrazole-4-carboxamides were rationally designed, synthesized, and their structures were characterized by 1H NMR, 13C NMR and HRMS. Preliminary bioassay showed that four compounds 8g, 8j, 8o and...
-
Article
Comprehensive multi-attribute method workflow for biotherapeutic characterization and current good manufacturing practices testing
The multi-attribute method (MAM) is a liquid chromatography-mass spectrometry (LC-MS)-based method that is used to directly characterize and monitor numerous product quality attributes (PQAs) at the amino acid...
-
Article
Retinoblastoma-associated protein is important for TRIM24-mediated activation of the mTOR signaling pathway through DUSP2 action in prostate cancer
RB transcriptional corepressor 1 (RB) deletion is the most important genomic factor associated with the prognosis of castration-resistant prostate cancer (CRPC) patients receiving androgen receptor (AR) signaling...
