3 Result(s)
within
Article
Chungyong Han
Antibodies
Medical Microbiology
-
Article
Open Access4-1BB-4-1BBL cis-interaction contributes to the survival of self-reactive CD8+ T cell
-
Article
Open AccessChronic activation of 4-1BB signaling induces granuloma development in tumor-draining lymph nodes that is detrimental to subsequent CD8+ T cell responses
The antitumor capabilities of agonistic anti-4-1BB mAbs have made them an attractive target for tumor immunotherapy. However, the adverse side effects associated with agonist antibodies have hindered their cli...
-
Article
4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8+ T cell proliferation
4-1BB (CD137) is a strong enhancer of the proliferation of CD8+ T cells. Since these cells require increased production of energy and biomass to support their proliferation, we hypothesized that 4-1BB signaling a...
