3 Result(s)
within
Science, Humanities and Social Sciences, multidisciplinary
Science, multidisciplinary
Chungyong Han
Article
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Article
Open AccessStructure of TCR and antigen complexes at an immunodominant CTL epitope in HIV-1 infection
We investigated the crystal structure of an HLA-A*2402-restricted CTL epitope in the HIV-1 nef gene (Nef134-10) before (pHLA) or after TCR docking. The wild type epitope and two escape mutants were included in th...
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Article
Open AccessDesensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression
Chimeric antigen receptor (CAR) T cell therapy is an effective method for treating specific cancers. CARs are normally designed to recognize antigens, which are highly expressed on malignant cells but not on T...
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Article
Open AccessAdoptive immunotherapy with transient anti-CD4 treatment enhances anti-tumor response by increasing IL-18Rαhi CD8+ T cells
Adoptive T cell therapy (ACT) requires lymphodepletion preconditioning to eliminate immune-suppressive elements and enable efficient engraftment of adoptively transferred tumor-reactive T cells. As anti-CD4 mo...
