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  1. No Access

    Article

    The wound-healing effect of 7,3′,4′-trimethoxyflavone through increased levels of prostaglandin E2 by 15-hydroxyprostaglandin dehydrogenase inhibition

    To find an inhibitor of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) that rapidly metabolises Prostaglandin E2 (PGE2) as a mediator of wound healing, we examined seven flavonoids for this role.

    Kyung Hoon Sun, Sandeep Karna, Young-Sook Moon, Hoon Cho… in Biotechnology Letters (2017)

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    Article

    Histone H4 deacetylation down-regulates catalase gene expression in doxorubicin-resistant AML subline

    We explored if epigenetic mechanisms could be involved in the down-regulated expression of catalase gene (CAT) in the doxorubicin-resistant acute myelogenous leukemia (AML)-2/DX100 cells. Down-regulated CAT expre...

    Tae-Bum Lee, Young-Sook Moon, Cheol-Hee Choi in Cell Biology and Toxicology (2012)

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    Article

    Detection of drug transporter expression using a 25-multiplex RT-PCR assay

    Membrane transporters play important roles in mediating chemoresistance and chemosensitivity of tumor cells. Five sets of 5 genes were designed to simultaneously detect drug transporter expression in a single ...

    Tae-Bum Lee, Cheol-Hee Choi in Biotechnology Letters (2009)

  4. No Access

    Article

    Design of novel analogues with potent antibiotic activity based on the antimicrobial peptide, HP(2-9)-ME(1-12)

    To develop novel antibiotic peptides useful as therapeutic drugs, a number of analogues were designed to increase the hydrophobic helix region either by Trp-substitution or net positive charge increase by Lys-...

    Yoonkyung Park, Hee Nam Kim, Soon Nang Park, Seung-Hwan Jang… in Biotechnology Letters (2004)

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    Article

    Advantages of the doxorubicin-resistant, acute myelogenous leukemia cell line, AML-2/DX100, for the screening of multidrug resistance protein inhibitors and pro-oxidants

    The doxorubicin-resistant, acute myelogenous leukemia cell line, AML-2/DX100, characterized by the over-expression of multidrug resistance protein (MRP) and the down-regulation of catalase, has advantages for ...

    Young-Don Min, **-Cheol Yoo, Cheol-Hee Choi in Biotechnology Letters (2002)

  6. No Access

    Article

    Importance of the length of the N- and C-terminal regions of Helicobacter pylori ribosomal protein L1 (RPL1) on its antimicrobial activity

    HP (2-20) (AKKVFKRLEKLFSKIQNDK-NH2) is an antibacterial 19-mer peptide derived from the N-terminal region of Helicobacter pylori ribosomal protein L1 (RPL1). Several truncated peptides were synthesized to investi...

    Yoonkyung Park, Dong Gun Lee, Hee Nam Kim, Hyung Keun Kim… in Biotechnology Letters (2002)

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    Article

    Antibacterial activities of peptides designed as hybrids of antimicrobial peptides

    Hybrid peptides (HP-MA, HP-ME), each of 20 residues and incorporating 2–9 residues of Helicobacter pylori ribosomal protein L1 (HP) and 1–12 residues of magainin 2 and melittin, were designed. The antibiotic acti...

    Hyung Keun Kim, Dong Gun Lee, Yoonkyung Park, Hee Nam Kim… in Biotechnology Letters (2002)

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    Article

    Reactive Oxygen Species-specific Mechanisms of Drug Resistance in Paraquat-resistant Acute Myelogenous Leukemia Sublines

    Reactive oxygen species (ROS)-specific mechanisms of drug resistance were explored in paraquat (PQ)-resistant acute myelogenous leukemia cell (OCI/AML-2) sublines. For this, PQ-resistant AML sublines, AML-2/PQ...

    Cheol-Hee Choi, Hyang-Sook Kim, Oh-Seong Kweon, Tae-Bum Lee… in Molecules and Cells (2000)