7 Result(s)
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Article
Open AccessReal-world practice of conversion surgery for unresectable hepatocellular carcinoma - a single center data of 26 consecutive patients
To understand the proportion of uHCC (unresectable hepatocellular carcinoma) patients who achieve successful conversion resection in a high-volume setting with state of the art treatment options.
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Article
Open AccessA novel treatment strategy for lapatinib resistance in a subset of HER2-amplified gastric cancer
Gastric cancer (GC) is one of the leading causes of cancer-related deaths worldwide. Human epidermal growth factor receptor 2 (HER2) amplification occurs in approximately 13–23% of all GC cases and patients wi...
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Article
Open AccessA novel CD4+ CTL subtype characterized by chemotaxis and inflammation is involved in the pathogenesis of Graves’ orbitopathy
Graves’ orbitopathy (GO), the most severe manifestation of Graves’ hyperthyroidism (GH), is an autoimmune-mediated inflammatory disorder, and treatments often exhibit a low efficacy. CD4+ T cells have been rep...
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Article
Open AccessAmplification of transglutaminase 2 enhances tumor-promoting inflammation in gastric cancers
Tumor-promoting inflammation is a hallmark of cancer and is highly associated with tumor progression, angiogenesis, and metastasis. Tumor-associated macrophages (TAMs) are major drivers of tumor-promoting infl...
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Article
Open AccessHigh prevalence of TP53 mutations is associated with poor survival and an EMT signature in gliosarcoma patients
Gliosarcoma (GS) is a rare variant (2%) of glioblastoma (GBM) that poses clinical genomic challenges because of its poor prognosis and limited genomic information. To gain a comprehensive view of the genomic a...
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Article
Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences
Chris Tyler-Smith, Carlos Bustamante and colleagues report an analysis of 1,244 human Y chromosomes from the 1000 Genomes Project. They find that copy number variants have a higher predicted functional impact ...
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Article
Engineering microdeletions and microduplications by targeting segmental duplications with CRISPR
Recurrent, reciprocal genomic disorders due to non-allelic homologous recombination (NAHR) are a major cause of human disease. The authors developed a CRISPR/Cas9 genome engineering method that directly target...
