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Article
Alpha-synuclein and Parkinson's disease
The involvement of α-synuclein in neurodegenerative diseases was first suspected after the isolation of an α-synuclein fragment (NAC) from amyloid plaques in Alzheimer's disease (AD). Later, two different α-synu...
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Article
The parkin gene and its phenotype
Mutations of the parkin gene on chromosome 6 cause autosomal recessive, early onset parkinsonism. This is the most frequent form of monogenic parkinsonism so far identified. The associated phenotypical spectrum ...
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Article
Ultrastructural localization of parkin in the rat brainstem, thalamus and basal ganglia
The parkin gene encodes a 52 kd putative E3 ubiquitin-protein ligase involved in an autosomal recessive form of early onset parkinsonism. Parkin ultrastructural localization was studied by immunohistochemistry in...
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Article
Parkin Modulates Gene Expression in Control and Ceramide-Treated PC12 Cells
Mutations in the parkin gene cause autosomal-recessive early-onset parkinsonism as a result of the degeneration of mesencephalic dopaminergic neurons. In cell culture models, parkin expression has been shown to p...
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Article
Polymorphisms in the proteasomal subunit alpha4 are not associated with Parkinson's disease