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    Alpha-synuclein and Parkinson's disease

    The involvement of α-synuclein in neurodegenerative diseases was first suspected after the isolation of an α-synuclein fragment (NAC) from amyloid plaques in Alzheimer's disease (AD). Later, two different α-synu...

    C. B. Lücking, A. Brice* in Cellular and Molecular Life Sciences CMLS (2000)

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    The parkin gene and its phenotype

    Mutations of the parkin gene on chromosome 6 cause autosomal recessive, early onset parkinsonism. This is the most frequent form of monogenic parkinsonism so far identified. The associated phenotypical spectrum ...

    V. Bonifati, G. De Michele, C. B. Lücking, A. Dürr, E. Fabrizio in Neurological Sciences (2001)

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    Ultrastructural localization of parkin in the rat brainstem, thalamus and basal ganglia

    The parkin gene encodes a 52 kd putative E3 ubiquitin-protein ligase involved in an autosomal recessive form of early onset parkinsonism. Parkin ultrastructural localization was studied by immunohistochemistry in...

    A. Mouatt-Prigent, M.-P. Muriel, W.-J. Gu in Journal of Neural Transmission (2004)

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    Parkin Modulates Gene Expression in Control and Ceramide-Treated PC12 Cells

    Mutations in the parkin gene cause autosomal-recessive early-onset parkinsonism as a result of the degeneration of mesencephalic dopaminergic neurons. In cell culture models, parkin expression has been shown to p...

    P. G. Unschuld, J. Dächsel, F. Darios, A. Kohlmann in Molecular Biology Reports (2006)

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    Article

    Polymorphisms in the proteasomal subunit alpha4 are not associated with Parkinson's disease

    C. B. Lücking, P. Lichtner, M. Dichgans, T. Illig, C. Gieger in Journal of Neurology (2008)