17 Result(s)
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Life Sciences
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Regulation of cell differentiation to promote pullulan synthesis in Aureobasidium pullulans NG
Pullulan is a polymer produced by Aureobasidium spp. The yield of pullulan production can be impacted by the cellular differentiation of Aureobasidium spp., which changes with alterations in the growth environmen...
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Open AccessThe analysis of the function, diversity, and evolution of the Bacillus phage genome
Phages play a pivotal role in the evolution of microbial populations. The interactions between phages and their hosts are complex and may vary in response to host physiology and environmental conditions. Here,...
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Open AccessThe long non-coding RNA keratin-7 antisense acts as a new tumor suppressor to inhibit tumorigenesis and enhance apoptosis in lung and breast cancers
Expression of the long non-coding RNA (lncRNA) keratin-7 antisense (KRT7-AS) is downregulated in various types of cancer; however, the impact of KRT7-AS deficiency on tumorigenesis and apoptosis is enigmatic. ...
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Design and Antibacterial Mechanism of Peptides Derived from Sakacin P
Pseudomonas aeruginosa easily obtains multidrug resistance and forms biofilm. These properties bring more challenges to its control. Antimicrobial peptides (AMPs) can inhibit the formation of biofilms. However th...
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The construction of a dual-functional strain that produces both polysaccharides and sulfotransferases
Heparosan is used as the starting polysaccharide sulfated using sulfotransferase to generate fully elaborate heparin, a widely used clinical drug. However, the preparation of heparosan and enzymes was consider...
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Metabolomics integrated with transcriptomics: assessing the central metabolism of marine red yeast Sporobolomyces pararoseus under salinity stress
Salinity stress is one of the most serious environmental issues in agricultural regions worldwide. Excess salinity inhibits root growth of various crops, and results in reductions of yield. It is of crucial to...
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Heparin stimulates biofilm formation of Escherichia coli strain Nissle 1917
Escherichia coli strain Nissle 1917 (EcN), a gut probiotic competing with pathogenic bacteria, has been used to attenuate various intestinal dysfunctions. Heparin is a sulfated glycosaminoglycan enriched in the h...
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Super-enhancer-driven metabolic reprogramming promotes cystogenesis in autosomal dominant polycystic kidney disease
Metabolic reprogramming is emerging as a key pathological contributor to the progression of autosomal dominant polycystic kidney disease (ADPKD), but the molecular mechanisms underlying dysregulated cellular m...
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Open AccessU-shaped association between plasma sphingosine-1-phosphate levels and mortality in patients with chronic systolic heart failure: a prospective cohort study
The endogenous lipid molecule sphingosine-1-phosphate (S1P) has received attention in the cardiovascular field due to its significant cardioprotective effects, as revealed in animal studies. The purpose of our...
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Open AccessFibrotic liver microenvironment promotes Dll4 and SDF-1-dependent T-cell lineage development
The reconstitution of the T-cell repertoire and quantity is a major challenge in the clinical management of HIV infection/AIDS, cancer, and aging-associated diseases. We previously showed that autologous bone ...
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Open AccessIFNγ and TNFα synergistically induce apoptosis of mesenchymal stem/stromal cells via the induction of nitric oxide
Mesenchymal stem/stromal cells (MSCs) have been widely used to treat various inflammatory diseases. The immunomodulatory capabilities of MSCs are usually licensed by inflammatory cytokines and may vary dependi...
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Open AccessRNA sequencing and anthocyanin synthesis-related genes expression analyses in white-fruited Vaccinium uliginosum
Vaccinium uliginosum (Ericaceae) is an important wild berry having high economic value. The white-fruited V. uliginosum variety found in the wild lacks anthocyanin and bears silvery white fruits. Hence, it is a g...
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Apamin-Sensitive K+ Current Upregulation in Volume-Overload Heart Failure is Associated with the Decreased Interaction of CK2 with SK2
Recent studies have shown that the sensitivity of apamin-sensitive K+ current (I KAS, mediated by apamin-sensitive small conductance calcium-activated potassium channels subunits) to intra...
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Bisoprolol reversed small conductance calcium-activated potassium channel (SK) remodeling in a volume-overload rat model
A recent study indicated that apamin-sensitive current (I KAS, mediated by apamin-sensitive small conductance calcium-activated potassium channels subunits) density significantly increased in hear...
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Leaf-level plasticity of Salix gordejevii in fixed dunes compared with lowlands in Hunshandake Sandland, North China
To cope with adverse environments, the majority of indigenous plants in arid regions possess adaptive plasticity after long-term evolution. Leaf-level morphology, anatomy, biochemical properties, diurnal water...
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Insulin-like growth factor 2 as a candidate gene influencing growth and carcass traits and its bialleleic expression in chicken
We have identified DNA polymorphisms in the gene of insulin-like growth factor 2 by PCR-SSCP in a resource population, which was generated by Silky reciprocally crossing to Broilers. A C →G mutation was detect...
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Comparative analysis of the pig BAC sequence involved in the regulation of myostatin gene
Myostatin (GDF8, MSTN) is a member of the transforming growth factor beta superfamily that is essential for proper regulation of skeletal muscle mass. In order to study its expression and regulatory mechanism ...
