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  1. Article

    Open Access

    Molecular signatures of angiogenesis inhibitors: a single-embryo untargeted metabolomics approach in zebrafish

    Angiogenesis is a key process in embryonic development, a disruption of this process can lead to severe developmental defects, such as limb malformations. The identification of molecular perturbations represen...

    Pia Wilhelmi, Volker Haake, Franziska M. Zickgraf, Varun Giri… in Archives of Toxicology (2024)

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  2. Article

    Open Access

    Application of high throughput in vitro metabolomics for hepatotoxicity mode of action characterization and mechanistic-anchored point of departure derivation: a case study with nitrofurantoin

    Omics techniques have been increasingly recognized as promising tools for Next Generation Risk Assessment. Targeted metabolomics offer the advantage of providing readily interpretable mechanistic information a...

    Sabina Ramirez-Hincapie, Barbara Birk, Philipp Ternes, Varun Giri… in Archives of Toxicology (2023)

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  3. Article

    Open Access

    In vitro-to-in vivo extrapolation (IVIVE) by PBTK modeling for animal-free risk assessment approaches of potential endocrine-disrupting compounds

    While in vitro testing is used to identify hazards of chemicals, nominal in vitro assay concentrations may misrepresent potential in vivo effects and do not provide dose–response data which can be used for a r...

    Eric Fabian, Caroline Gomes, Barbara Birk, Tabitha Williford… in Archives of Toxicology (2019)

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