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  1. No Access

    Article

    Targeting central serotonergic neurons with lentiviral vectors based on a transcriptional amplification strategy

    Numerous pathological processes have been linked to disorders of the central 5-hydroxytryptamine (5HT) system but the possibility of gene therapy through modulation of 5HT system remained unexplored due to the...

    K Benzekhroufa, B-H Liu, A G Teschemacher, S Kasparov in Gene Therapy (2009)

  2. No Access

    Article

    Repeated intrathecal administration of plasmid DNA complexed with polyethylene glycol-grafted polyethylenimine led to prolonged transgene expression in the spinal cord

    Gene delivery into the spinal cord provides a potential approach to the treatment of spinal cord traumatic injury, amyotrophic lateral sclerosis, and spinal muscular atrophy. These disorders progress over long...

    L Shi, G P Tang, S J Gao, Y X Ma, B H Liu, Y Li, J M Zeng, Y K Ng… in Gene Therapy (2003)