11 Result(s)

Article

The thrombin inhibitor, argatroban, inhibits breast cancer metastasis to bone

Breast cancer has the potential to metastasize to bone, causing debilitating symptoms. Although many tumor cells have thrombin-generating systems originating from tissue factor (TF), therapy in terms of the co...

Kunihiro Asanuma, Hiroki Wakabayashi, Takayuki Okamoto, Yumiko Asanuma… in Breast Cancer (2013)

Article

A novel hyperthermia treatment for bone metastases using magnetic materials

Patients with bone metastases in the extremities sometimes require surgical intervention to prevent deterioration of quality of life due to a pathological fracture. The use of localized radiotherapy combined w...

Akihiko Matsumine, Kenji Takegami… in International Journal of Clinical Oncology (2011)

Article

Management of small pulmonary nodules in patients with sarcoma

Small pulmonary nodules in patients with sarcoma are problematic, because it is difficult to distinguish such small metastatic nodules from benign. The purpose of this study was to establish management guideli...

Tomoki Nakamura, Akihiko Matsumine, Rui Niimi… in Clinical & Experimental Metastasis (2009)

Article

Usefulness of limb salvage surgery for bone and soft tissue sarcomas of the distal lower leg

The usefulness of limb salvage surgery for distal lower leg sarcoma remains controversial. We analyzed the long-term prognosis, limb function, and complications after limb salvage treatment of patients with di...

Rui Niimi, Akihiko Matsumine… in Journal of Cancer Research and Clinical On… (2008)

Article

Common variants in DVWA on chromosome 3p24.3 are associated with susceptibility to knee osteoarthritis

Shiro Ikegawa and colleagues identify a variant in a newly identified gene, DVWA, that is associated with susceptibility to knee osteoarthritis. DVWA contains von Willebrand factor domains and is expressed specif...

Yoshinari Miyamoto, Dongquan Shi, Masahiro Nakajima, Kouichi Ozaki… in Nature Genetics (2008)

Article

Novel hyperthermia for metastatic bone tumors with magnetic materials by generating an alternating electromagnetic field

We have developed a novel hyperthermic treatment modality using magnetic materials for metastatic bone tumors. The purpose of this study is to show the results of novel hyperthermia for metastatic bone tumors....

Akihiko Matsumine, Katsuyuki Kusuzaki… in Clinical & Experimental Metastasis (2007)

Article

A functional polymorphism in the 5′ UTR of GDF5 is associated with susceptibility to osteoarthritis

Osteoarthritis (MIM 165720), characterized by degeneration of articular cartilage, is the most common form of human arthritis and a major concern for aging societies worldwide^1,2,3. Epidemiological and genetic st...

Yoshinari Miyamoto, Akihiko Mabuchi, Dongquan Shi, Toshikazu Kubo… in Nature Genetics (2007)

Article

Low-dose Methotrexate Inhibits Lung Metastasis and Lengthens Survival in Rat Osteosarcoma

Lung metastasis is the most crucial event affecting the treatment of osteosarcoma and is dependent on tumor angiogenesis. To improve the prognosis for patients with osteosarcoma, prevention of lung metastasis ...

Ryota Tomoda, Masashi Seto, Yasunari Hioki… in Clinical & Experimental Metastasis (2005)

Article

An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis

Osteoarthritis is the most common form of human arthritis. We investigated the potential role of asporin, an extracellular matrix component expressed abundantly in the articular cartilage of individuals with o...

Hideki Kizawa, Ikuyo Kou, Aritoshi Iida, Akihiro Sudo… in Nature Genetics (2005)

Article

Bone and soft tissue sarcomas: Summary of the Third United States/Japan Clinical Trials Summit (Seattle, Washington)

Atsumasa Uchida, Masanori Fukushima… in Journal of Cancer Research and Clinical On… (1997)