62 Result(s)

Article

Bone and soft tissue sarcomas: Summary of the Third United States/Japan Clinical Trials Summit (Seattle, Washington)

Atsumasa Uchida, Masanori Fukushima… in Journal of Cancer Research and Clinical On… (1997)

Article

Expression of gp145 ^trkB in the early stage of Schwann cell tube formation

: We investigated the expression of tyrosine kinase receptors (trkBs) and their ligand, brain-derived neurotrophic factor (BDNF), in isolated sciatic nerve segments of rat in a silicone chamber model devoid of ax...

Dequan Shi, Hitoshi Hirata, Hiroki Sasaki, Akimasa Morita… in Journal of Orthopaedic Science (1999)

Article

Molecular diagnosis and gene therapy in musculoskeletal tumors

Significant progress has occurred in the molecular analyses of bone and soft-tissue tumors, and genetic studies have led to the development of important new diagnostic tools for the clinical management of pat...

Atsumasa Uchida, Masashi Seto, Nobuyuki Hashimoto… in Journal of Orthopaedic Science (2000)

Article

Limb-lengthening and angular correction for dysplasia epiphysealis hemimelica

We report a patient with severe varus deformity and tibial shortening caused by dysplasia epiphysealis hemimelica (DEH), a rare skeletal developmental disorder characterized by an osteocartilaginous tumor ari...

Masaki Nishiyama, Eiji Nii, Kouji Akeda, Atsumasa Uchida in Journal of Orthopaedic Science (2001)

Article

Length of the ribs in patients with idiopathic scoliosis

There have been few reports of actual measurements of rib length in patients with idiopathic scoliosis. We measured the lengths of the 7th to 12th ribs in 28 patients with idiopathic scoliosis with right conv...

Yuichi Kasai, Kenji Takegami, Atsumasa Uchida in Archives of Orthopaedic and Trauma Surgery (2002)

Article

Effect of hyperthermia by magnetite cement on tumor-induced bone destruction

 Our study focuses on the antineoplasmic action of hyperthermia. In this study, use of a heat-generating cement was exploited for the management of pathological and impending fractures in malignancies. The cem...

Masaya Kusaka, Kenji Takegami, Akihiro Sudo… in Journal of Orthopaedic Science (2002)

Article

Heterotopic ossification around distal femur after total knee arthroplasty

Heterotopic ossification after total knee arthroplasty is not well recognized. We found heterotopic ossification around the distal femur in 10 (5%) of 221 knees after primary total knee arthroplasty and evalu...

Masahiro Hasegawa, Toshiro Ohashi… in Archives of Orthopaedic and Trauma Surgery (2002)

Article

A study of patients with spinal disease using Maudsley Personality Inventory

We administered the Maudsley Personality Inventory (MPI) preoperatively to 303 patients with spinal diseases about to undergo surgery. Patients younger than 20 years, patients previously treated in the Departm...

Yuichi Kasai, Kenji Takegami, Atsumasa Uchida in International Orthopaedics (2004)

Article

New cell lines with chondrocytic phenotypes from human chondrosarcoma

In the present study, we investigated chondrocytic characterization for newly established human chondrosarcoma cell lines. A chondrosarcoma cell line, HCS-TG, was established by the implantation of grade-2 hum...

Ikuo Kudawara, Nobuhito Araki, Akira Myoui, Yoichi Kato, Atsumasa Uchida… in Virchows Archiv (2004)

Article

Metastatic bone disease: pathogenesis and new strategies for treatment

Bone is the third leading site of metastatic disease, after the lung and liver. Pain, pathological fractures, neurological deficits, and forced immobilization significantly decrease the quality of life of pati...

Atsumasa Uchida, Hiroki Wakabayashi, Noritaka Okuyama… in Journal of Orthopaedic Science (2004)

Article

The functional interaction between CD98 and CD147 in regulation of virus-induced cell fusion and osteoclast formation

Membrane fusion is an important event in the functioning of a living organism. Life starts as a sperm fuses with the membrane of an egg, leading to its fertilization. Membrane fusion is also required for myoge...

Kouki Mori, Makoto Nishimura, Masato Tsurudome… in Medical Microbiology and Immunology (2004)

Article

An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis

Osteoarthritis is the most common form of human arthritis. We investigated the potential role of asporin, an extracellular matrix component expressed abundantly in the articular cartilage of individuals with o...

Hideki Kizawa, Ikuyo Kou, Aritoshi Iida, Akihiro Sudo… in Nature Genetics (2005)

Article

Rapidly destructive coxopathy after subchondral insufficiency fracture of the femoral head

Rapidly destructive coxopathy (RDC) is a rare disorder, and its pathophysiology is unknown. Here, we report a case of RDC evaluated by roentgenography and magnetic resonance imaging, from the onset of hip pain...

Rui Niimi, Masahiro Hasegawa, Akihiro Sudo… in Archives of Orthopaedic and Trauma Surgery (2005)

Article

Low-dose Methotrexate Inhibits Lung Metastasis and Lengthens Survival in Rat Osteosarcoma

Lung metastasis is the most crucial event affecting the treatment of osteosarcoma and is dependent on tumor angiogenesis. To improve the prognosis for patients with osteosarcoma, prevention of lung metastasis ...

Ryota Tomoda, Masashi Seto, Yasunari Hioki… in Clinical & Experimental Metastasis (2005)

Article

Pre-and postoperative psychological characteristics in mothers of patients with idiopathic scoliosis

The purpose of the present study was to clarify changes in the psychological state of mothers of patients with idiopathic scoliosis, and to clarify relationships between the psychological states of the mothers...

Yuichi Kasai, Koichiro Morishita, Eiji Kawakita, Tetsushi Kondo… in European Spine Journal (2006)

Article

Bilateral hip fractures

In the past, patients admitted for hip fractures had often sustained a contralateral hip fracture. The incidence of bilateral hip fractures has been reported to be 5–10%, and in the future the number of bilate...

Tatsuki Fukushima, Akihiro Sudo, Atsumasa Uchida in Journal of Orthopaedic Science (2006)

Article

Expression of hypoxia-inducible factor (HIF)-1α as a biomarker of outcome in soft-tissue sarcomas

Hypoxia-inducible factor (HIF)-1α is a transcription factor that supports the adaptation of human cancer cells to hypoxia and tumor growth and progression. The overexpression of HIF-1α protein has been reporte...

Ken Shintani, Akihiko Matsumine, Katsuyuki Kusuzaki, Takao Matsubara… in Virchows Archiv (2006)

Article

A large metallic cyst caused by wear particles after total knee arthroplasty

A symptomatic cyst is an uncommon complication after total knee arthroplasty (TKA). We present a case of a 77-year-old woman with a large cyst in the right knee caused by metal wear debris from the failure of ...

Rui Niimi, Masahiro Hasegawa, Akihiro Sudo… in Archives of Orthopaedic and Trauma Surgery (2007)

Article

A functional polymorphism in the 5′ UTR of GDF5 is associated with susceptibility to osteoarthritis

Osteoarthritis (MIM 165720), characterized by degeneration of articular cartilage, is the most common form of human arthritis and a major concern for aging societies worldwide^1,2,3. Epidemiological and genetic st...

Yoshinari Miyamoto, Akihiko Mabuchi, Dongquan Shi, Toshikazu Kubo… in Nature Genetics (2007)