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Article
Elevated soluble platelet glycoprotein VI is a useful marker for DVT in postoperative patients treated with edoxaban
Prevention of deep vein thrombosis (DVT) is important in patients undergoing major orthopedic surgery. Although the detection of an elevated d-dimer level is useful for predicting DVT, it is not efficacious in p...
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Article
The thrombin inhibitor, argatroban, inhibits breast cancer metastasis to bone
Breast cancer has the potential to metastasize to bone, causing debilitating symptoms. Although many tumor cells have thrombin-generating systems originating from tissue factor (TF), therapy in terms of the co...
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Article
Open AccessSoluble Neural-cadherin as a novel biomarker for malignant bone and soft tissue tumors
Neural-cadherin (N-cadherin) is one of the most important molecules involved in tissue morphogenesis, wound healing, and the maintenance of tissue integrity. Recently, the cleavage of N-cadherin has become a f...
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Article
Increased fibrinolysis increases bleeding in orthopedic patients receiving prophylactic fondaparinux
We evaluated hemostatic markers in patients who underwent major orthopedic surgery, including total hip and total knee arthroplasty, and were treated for the prophylaxis of deep vein thrombosis (DVT) with or w...
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Article
Monitoring for anti-Xa activity for prophylactic administration of Fondaparinux in patients with artificial joint replacement
The efficacy of measuring anti-Xa activity was evaluated in major orthopedic surgery patients receiving thrombo-prophylaxis with Fondaparinux. Although 98 orthopedic patients including those receiving total hi...
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Article
A novel hyperthermia treatment for bone metastases using magnetic materials
Patients with bone metastases in the extremities sometimes require surgical intervention to prevent deterioration of quality of life due to a pathological fracture. The use of localized radiotherapy combined w...
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Article
Epithelioid hemangioendothelioma after radiotherapy for congenital hemangioma: a case report
A rare case of post-radiation epithelioid hemangioendothelioma arising in a congenital hemangioma of the lower leg 18 years after radiotherapy is reported. At 7 years of age, the patient underwent partial rese...
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Article
Management of small pulmonary nodules in patients with sarcoma
Small pulmonary nodules in patients with sarcoma are problematic, because it is difficult to distinguish such small metastatic nodules from benign. The purpose of this study was to establish management guideli...
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Article
Cut-off values of D-dimer and soluble fibrin for prediction of deep vein thrombosis after orthopaedic surgery
Soluble fibrin (SF) and D-dimer are considered to be useful for the diagnosis of thrombosis; however, the efficacy of the diagnosis of deep vein thrombosis (DVT) after orthopaedic surgery by SF and D-dimer is ...
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Article
Elevated levels of soluble fibrin in patients with venous thromboembolism
The fibrin-related markers (FRMs), including soluble fibrin (SF), d-dimer and fibrin and fibrinogen degradation products (FDP) are considered to be useful for the diagnosis of thrombosis; however, evidence for th...
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Article
Usefulness of limb salvage surgery for bone and soft tissue sarcomas of the distal lower leg
The usefulness of limb salvage surgery for distal lower leg sarcoma remains controversial. We analyzed the long-term prognosis, limb function, and complications after limb salvage treatment of patients with di...
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Article
Primary osteosarcoma of the lung: a case report and review of the literature
Primary osteosarcoma of the lung is exceedingly rare. A 72-year-old man was admitted to our hospital; a primary osteosarcoma of the lung was diagnosed following computed tomography-guided needle biopsy. He die...
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Article
Negative predictive value of d-dimer for diagnosis of venous thromboembolism
The d-dimer levels are considered to be useful for the diagnosis of thrombosis, and they can be clinically used as a negative predictive value (NPV). However, evidence for the efficacy of diagnosing thrombosis ba...
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Article
Novel hyperthermia for metastatic bone tumors with magnetic materials by generating an alternating electromagnetic field
We have developed a novel hyperthermic treatment modality using magnetic materials for metastatic bone tumors. The purpose of this study is to show the results of novel hyperthermia for metastatic bone tumors....
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Article
Low-dose Methotrexate Inhibits Lung Metastasis and Lengthens Survival in Rat Osteosarcoma
Lung metastasis is the most crucial event affecting the treatment of osteosarcoma and is dependent on tumor angiogenesis. To improve the prognosis for patients with osteosarcoma, prevention of lung metastasis ...
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Article
Bone and soft tissue sarcomas: Summary of the Third United States/Japan Clinical Trials Summit (Seattle, Washington)