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    Article

    Elevated soluble platelet glycoprotein VI is a useful marker for DVT in postoperative patients treated with edoxaban

    Prevention of deep vein thrombosis (DVT) is important in patients undergoing major orthopedic surgery. Although the detection of an elevated d-dimer level is useful for predicting DVT, it is not efficacious in p...

    Takumi Aota, Katsuki Naitoh, Hideo Wada in International Journal of Hematology (2014)

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    Article

    The thrombin inhibitor, argatroban, inhibits breast cancer metastasis to bone

    Breast cancer has the potential to metastasize to bone, causing debilitating symptoms. Although many tumor cells have thrombin-generating systems originating from tissue factor (TF), therapy in terms of the co...

    Kunihiro Asanuma, Hiroki Wakabayashi, Takayuki Okamoto, Yumiko Asanuma in Breast Cancer (2013)

  3. Article

    Open Access

    Soluble Neural-cadherin as a novel biomarker for malignant bone and soft tissue tumors

    Neural-cadherin (N-cadherin) is one of the most important molecules involved in tissue morphogenesis, wound healing, and the maintenance of tissue integrity. Recently, the cleavage of N-cadherin has become a f...

    Rui Niimi, Akihiko Matsumine, Takahiro Iino, Shigeto Nakazora in BMC Cancer (2013)

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    Article

    Increased fibrinolysis increases bleeding in orthopedic patients receiving prophylactic fondaparinux

    We evaluated hemostatic markers in patients who underwent major orthopedic surgery, including total hip and total knee arthroplasty, and were treated for the prophylaxis of deep vein thrombosis (DVT) with or w...

    Kakunoshin Yoshida, Hideo Wada, Masahiro Hasegawa in International Journal of Hematology (2012)

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    Article

    Monitoring for anti-Xa activity for prophylactic administration of Fondaparinux in patients with artificial joint replacement

    The efficacy of measuring anti-Xa activity was evaluated in major orthopedic surgery patients receiving thrombo-prophylaxis with Fondaparinux. Although 98 orthopedic patients including those receiving total hi...

    Kakunoshin Yoshida, Hideo Wada, Masahiro Hasegawa in International Journal of Hematology (2011)

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    Article

    A novel hyperthermia treatment for bone metastases using magnetic materials

    Patients with bone metastases in the extremities sometimes require surgical intervention to prevent deterioration of quality of life due to a pathological fracture. The use of localized radiotherapy combined w...

    Akihiko Matsumine, Kenji Takegami in International Journal of Clinical Oncology (2011)

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    Article

    Epithelioid hemangioendothelioma after radiotherapy for congenital hemangioma: a case report

    A rare case of post-radiation epithelioid hemangioendothelioma arising in a congenital hemangioma of the lower leg 18 years after radiotherapy is reported. At 7 years of age, the patient underwent partial rese...

    Rui Niimi, Akihiko Matsumine, Katsuyuki Kusuzaki, Ken Shintani in Medical Oncology (2010)

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    Article

    Management of small pulmonary nodules in patients with sarcoma

    Small pulmonary nodules in patients with sarcoma are problematic, because it is difficult to distinguish such small metastatic nodules from benign. The purpose of this study was to establish management guideli...

    Tomoki Nakamura, Akihiko Matsumine, Rui Niimi in Clinical & Experimental Metastasis (2009)

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    Article

    Cut-off values of D-dimer and soluble fibrin for prediction of deep vein thrombosis after orthopaedic surgery

    Soluble fibrin (SF) and D-dimer are considered to be useful for the diagnosis of thrombosis; however, the efficacy of the diagnosis of deep vein thrombosis (DVT) after orthopaedic surgery by SF and D-dimer is ...

    Akihiro Sudo, Hideo Wada, Tsutomu Nobori in International Journal of Hematology (2009)

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    Article

    Elevated levels of soluble fibrin in patients with venous thromboembolism

    The fibrin-related markers (FRMs), including soluble fibrin (SF), d-dimer and fibrin and fibrinogen degradation products (FDP) are considered to be useful for the diagnosis of thrombosis; however, evidence for th...

    Akihiro Tsuji, Hideo Wada, Takeshi Matsumoto in International Journal of Hematology (2008)

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    Article

    Usefulness of limb salvage surgery for bone and soft tissue sarcomas of the distal lower leg

    The usefulness of limb salvage surgery for distal lower leg sarcoma remains controversial. We analyzed the long-term prognosis, limb function, and complications after limb salvage treatment of patients with di...

    Rui Niimi, Akihiko Matsumine in Journal of Cancer Research and Clinical On… (2008)

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    Article

    Primary osteosarcoma of the lung: a case report and review of the literature

    Primary osteosarcoma of the lung is exceedingly rare. A 72-year-old man was admitted to our hospital; a primary osteosarcoma of the lung was diagnosed following computed tomography-guided needle biopsy. He die...

    Rui Niimi, Akihiko Matsumine, Katsuyuki Kusuzaki, Yasuhiro Inada in Medical Oncology (2008)

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    Article

    Negative predictive value of d-dimer for diagnosis of venous thromboembolism

    The d-dimer levels are considered to be useful for the diagnosis of thrombosis, and they can be clinically used as a negative predictive value (NPV). However, evidence for the efficacy of diagnosing thrombosis ba...

    Hideki Nomura, Hideo Wada, Toshiro Mizuno in International Journal of Hematology (2008)

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    Article

    Novel hyperthermia for metastatic bone tumors with magnetic materials by generating an alternating electromagnetic field

    We have developed a novel hyperthermic treatment modality using magnetic materials for metastatic bone tumors. The purpose of this study is to show the results of novel hyperthermia for metastatic bone tumors....

    Akihiko Matsumine, Katsuyuki Kusuzaki in Clinical & Experimental Metastasis (2007)

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    Article

    Low-dose Methotrexate Inhibits Lung Metastasis and Lengthens Survival in Rat Osteosarcoma

    Lung metastasis is the most crucial event affecting the treatment of osteosarcoma and is dependent on tumor angiogenesis. To improve the prognosis for patients with osteosarcoma, prevention of lung metastasis ...

    Ryota Tomoda, Masashi Seto, Yasunari Hioki in Clinical & Experimental Metastasis (2005)

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    Article

    Bone and soft tissue sarcomas: Summary of the Third United States/Japan Clinical Trials Summit (Seattle, Washington)

    Atsumasa Uchida, Masanori Fukushima in Journal of Cancer Research and Clinical On… (1997)