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  1. Article

    Open Access

    Soluble Neural-cadherin as a novel biomarker for malignant bone and soft tissue tumors

    Neural-cadherin (N-cadherin) is one of the most important molecules involved in tissue morphogenesis, wound healing, and the maintenance of tissue integrity. Recently, the cleavage of N-cadherin has become a f...

    Rui Niimi, Akihiko Matsumine, Takahiro Iino, Shigeto Nakazora… in BMC Cancer (2013)

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    Article

    Management of small pulmonary nodules in patients with sarcoma

    Small pulmonary nodules in patients with sarcoma are problematic, because it is difficult to distinguish such small metastatic nodules from benign. The purpose of this study was to establish management guideli...

    Tomoki Nakamura, Akihiko Matsumine, Rui Niimi… in Clinical & Experimental Metastasis (2009)

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    Article

    Common variants in DVWA on chromosome 3p24.3 are associated with susceptibility to knee osteoarthritis

    Shiro Ikegawa and colleagues identify a variant in a newly identified gene, DVWA, that is associated with susceptibility to knee osteoarthritis. DVWA contains von Willebrand factor domains and is expressed specif...

    Yoshinari Miyamoto, Dongquan Shi, Masahiro Nakajima, Kouichi Ozaki… in Nature Genetics (2008)

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    Article

    Novel hyperthermia for metastatic bone tumors with magnetic materials by generating an alternating electromagnetic field

    We have developed a novel hyperthermic treatment modality using magnetic materials for metastatic bone tumors. The purpose of this study is to show the results of novel hyperthermia for metastatic bone tumors....

    Akihiko Matsumine, Katsuyuki Kusuzaki… in Clinical & Experimental Metastasis (2007)

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    Article

    A functional polymorphism in the 5′ UTR of GDF5 is associated with susceptibility to osteoarthritis

    Osteoarthritis (MIM 165720), characterized by degeneration of articular cartilage, is the most common form of human arthritis and a major concern for aging societies worldwide1,2,3. Epidemiological and genetic st...

    Yoshinari Miyamoto, Akihiko Mabuchi, Dongquan Shi, Toshikazu Kubo… in Nature Genetics (2007)

  6. No Access

    Article

    Low-dose Methotrexate Inhibits Lung Metastasis and Lengthens Survival in Rat Osteosarcoma

    Lung metastasis is the most crucial event affecting the treatment of osteosarcoma and is dependent on tumor angiogenesis. To improve the prognosis for patients with osteosarcoma, prevention of lung metastasis ...

    Ryota Tomoda, Masashi Seto, Yasunari Hioki… in Clinical & Experimental Metastasis (2005)

  7. No Access

    Article

    An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis

    Osteoarthritis is the most common form of human arthritis. We investigated the potential role of asporin, an extracellular matrix component expressed abundantly in the articular cartilage of individuals with o...

    Hideki Kizawa, Ikuyo Kou, Aritoshi Iida, Akihiro Sudo… in Nature Genetics (2005)

  8. No Access

    Article

    The functional interaction between CD98 and CD147 in regulation of virus-induced cell fusion and osteoclast formation

    Membrane fusion is an important event in the functioning of a living organism. Life starts as a sperm fuses with the membrane of an egg, leading to its fertilization. Membrane fusion is also required for myoge...

    Kouki Mori, Makoto Nishimura, Masato Tsurudome… in Medical Microbiology and Immunology (2004)