9 Result(s)
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Article
Ashish Jain
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessInflammation drives pathogenesis of early intestinal failure-associated liver disease
Patients with intestinal failure who receive long-term parenteral nutrition (PN) often develop intestinal failure-associated liver disease (IFALD). Although there are identified risk factors, the early pathoge...
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Open AccessIntrinsic dichroism in amorphous and crystalline solids with helical light
Amorphous solids do not exhibit long-range order due to the disordered arrangement of atoms. They lack translational and rotational symmetry on a macroscopic scale and are therefore isotropic. As a result, dif...
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Open AccessImpact of concurrent diabetes on periodontal health in patients with acromegaly
Previous studies have suggested excess GH/IGF1 secretion in patients with acromegaly is protective for periodontal health. Diabetes is prevalent comorbidity in patients of acromegaly and is associated with wor...
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Open AccessDeciphering transcriptional regulation in human embryonic stem cells specified towards a trophoblast fate
Differentiated human embryonic stem cells (hESC) continue to provide a model for studying early trophoblast cells (TB), but many questions have been raised regarding their true identity. Therefore, we carried ...
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Open AccessKenny mediates selective autophagic degradation of the IKK complex to control innate immune responses
Selective autophagy is a catabolic process with which cellular material is specifically targeted for degradation by lysosomes. The function of selective autophagic degradation of self-components in the regulat...
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Microenvironmental autophagy promotes tumour growth
During early-stage tumour growth in Drosphila, tumour cells acquire necessary nutrients by triggering autophagy in surrounding cells in the tumour microenvironment.
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Open AccessBiochemical and genome sequence analyses of Megasphaera sp. strain DISK18 from dental plaque of a healthy individual reveals commensal lifestyle
Much of the work in periodontal microbiology in recent years has focused on identifying and understanding periodontal pathogens. As the majority of oral microbes have not yet been isolated in pure form, it is ...
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Open AccessIdentification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2–JNK signalling in breast cancer
The non-canonical Wnt/planar cell polarity (Wnt/PCP) pathway plays a crucial role in embryonic development. Recent work has linked defects of this pathway to breast cancer aggressiveness and proposed Wnt/PCP s...
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The deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cells
CYLD is a tumour suppressor gene mutated in familial cylindromatosis, a genetic disorder leading to the development of skin appendage tumours. It encodes a deubiquitinating enzyme that removes Lys63- or linear-li...
