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Article
Open AccessMassively integrated coexpression analysis reveals transcriptional regulation, evolution and cellular implications of the yeast noncanonical translatome
Recent studies uncovered pervasive transcription and translation of thousands of noncanonical open reading frames (nORFs) outside of annotated genes. The contribution of nORFs to cellular phenotypes is difficu...
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Article
De novo gene increases brain size
Comparative analysis of human and macaque brain transcripts together with experiments in mice and in a cortical organoid model show the de novo emergence of a hominoid-specific protein-coding gene implicated i...
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Article
Open AccessRNF219 regulates CCR4-NOT function in mRNA translation and deadenylation
Post-transcriptional regulatory mechanisms play a role in many biological contexts through the control of mRNA degradation, translation and localization. Here, we show that the RING finger protein RNF219 co-pu...
