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Open AccessDetermining clinical course of diffuse large B-cell lymphoma using targeted transcriptome and machine learning algorithms
Multiple studies have demonstrated that diffuse large B-cell lymphoma (DLBCL) can be divided into subgroups based on their biology; however, these biological subgroups overlap clinically. Using machine learnin...
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Article
Systemic Exposure of Rituximab Increased by Ibrutinib: Pharmacokinetic Results and Modeling Based on the HELIOS Trial
In the HELIOS trial, bendamustine/rituximab (BR) plus ibrutinib (BR-I) improved disease outcomes versus BR plus placebo in previously treated chronic lymphocytic leukemia/small lymphocytic lymphoma. Here, we desc...
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Article
Targeting B cell receptor signaling with ibrutinib in diffuse large B cell lymphoma
Clinical testing of BCR inhibition on DLBCL reveals determinants of response.