3 Result(s)
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Article
Adrienn Volak
English
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Article
Virus vector-mediated genetic modification of brain tumor stromal cells after intravenous delivery
The malignant primary brain tumor, glioblastoma (GBM) is generally incurable. New approaches are desperately needed. Adeno-associated virus (AAV) vector-mediated delivery of anti-tumor transgenes is a promisin...
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Article
Open AccessHigh levels of AAV vector integration into CRISPR-induced DNA breaks
Adeno-associated virus (AAV) vectors have shown promising results in preclinical models, but the genomic consequences of transduction with AAV vectors encoding CRISPR-Cas nucleases is still being examined. In ...
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Article
Open AccessIn vivo engineering of lymphocytes after systemic exosome-associated AAV delivery
Ex-vivo gene therapy using stem cells or T cells transduced by retroviral or lentiviral vectors has shown remarkable efficacy in the treatment of immunodeficiencies and cancer. However, the process is expensive, ...
