4 Result(s)
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Article
Adrian J. Lloyd
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessInhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine
D-cycloserine is an antibiotic which targets sequential bacterial cell wall peptidoglycan biosynthesis enzymes: alanine racemase and D-alanine:D-alanine ligase. By a combination of structural, chemical and mec...
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Article
Open AccessReconstruction of diaminopimelic acid biosynthesis allows characterisation of Mycobacterium tuberculosis N-succinyl-L,L-diaminopimelic acid desuccinylase
With the increased incidence of tuberculosis (TB) caused by Mycobacterium tuberculosis there is an urgent need for new and better anti-tubercular drugs. N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) is ...
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Article
Open AccessCarbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity
The rapid rise of multi-drug-resistant bacteria is a global healthcare crisis, and new antibiotics are urgently required, especially those with modes of action that have low-resistance potential. One promising...
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Article
Upper Jurassic Rocks Beneath the Bristol Channel
THE first results from a geological survey of the floor of the Bristol Channel, carried out during the spring of 1960, have already been reported1. Jurassic rocks were found “from the Holms westwards to beyond Il...
