![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
-
Article
Bioavailability of the Tablet Dosage Form of a Benzimidazole Derivative Possessing Antiplatelet Activity
The bioavailability of the tablet dosage form of pharmaceutical substance RU-891, i.e., 9-(3,4-dihydroxyphenacyl)-2,3-dihydroimidazo[1,2-a]benzimidazole hydrobromide, was investigated. The main pharmacokinetic pa...
-
Article
Quantitative Determination of Angipur Drug Substance in Blood Plasma by HPLC with Fluorescence Detection
A quantitative determination method using HPLC with fluorescence detection for the xanthine derivative 3-methyl-8-(piperazin-1-yl)-7-(thietan-3-yl)-1-ethyl-1H-purine-2,6(3H,7H)-dione hydrochloride (Angipur drug s...
-
Article
Biopharmaceutical Study of an Injectable Dosage Form of the New Antiaggregant Substance 3-Methyl-8-(Piperazin-1-yl)-7-(Thietan-3-yl)-1-Ethyl-1H-Purine-2,6(3H,7H)-Dione Hydrochloride
The pharmacokinetic parameters of the parent substance and the injectable dosage form of the new antiplatelet drug 3-methyl-8-(piperazin-1-yl)-7-(thietan-3-yl)-1-ethyl-1H-purine-2,6(3H,7H)-dione hydrochloride in ...
-
Article
Uracil Hydroxybenzamides as Potential Antidiabetic Prodrugs
A series of N1, N3-bis-hydroxybenzoyl, -acetoxybenzoyl, and -methoxybenzoyl uracil derivatives were synthesized. All compounds were screened for the ability to rupture protein cross links and antiglycating, chela...
-
Article
Synthesis and Pharmacological Activity of Trifluoromethyl-Containing Imidazo[1,2-A]Benzimidazoles
A series of 2-(4-trifluoromethylphenyl)- and 2-trifluoromethyl-9-dialkylaminoalkylimidazo[1,2-a]benzimidazoles were synthesized for the first time by reacting 2-amino-1-dialkylaminoalkylbenzimidazoles and 2-bromo...
-
Article
The Search for Pharmacologically Active Compounds Among the 2-Dialkylaminobenzimidazoles
Heating of substituted benzimidazole-2-sulfonic acids in the presence of excess quantities of secondary amines was used to synthesize dialkylaminobenzimidazoles. Experimental studies of potential antiarrhythmi...
-
Article
1-Substituted 2-Benzylaminobenzimidazoles with Phenyl Methoxyls: Synthesis, Computer Prediction, and Pharmacological Activity
Condensation of 1-substituted 2-aminobenzimidazoles with aromatic aldehydes produced the corresponding azomethines, reduction of which by sodium borohydride afforded 1-substituted 2-benzylaminobenzimidazoles. ...
-
Article
Synthesis and Pharmacological Activity of Amino Alcohols of the Indole Series
Opening of the oxirane ring in 1-oxiranylmethylindoles yielded new indole derivatives containing 1,2-amino alcohol residues at the nitrogen atom. Compounds were studied in vitro in relation to various types of...
-
Article
Synthesis and pharmacological activity of amides of 2-amino-3-indolylacrylic acid
Opening of the five-member ring of indolylmethyleneoxazolones with aliphatic amines was used to synthesize a series of amides of 2-amino-3-indolylacrylic acid. These compounds were studied in vitro in relation...
-
Article
Synthesis and pharmacological activity of 3-(n,n-disubstituted)acetamide-1-r-2-aminobenzimidazolium chlorides
A series of 3-(N,N-disubstituted)acetamide-1-R-2-aminobenzimidazolium chlorides were synthesized. Their pharmacological properties were studied. It was established that the synthesized substances decreased platel...
-
Article
Synthesis and pharmacological activity of salts of 3-acetyl-2-R-9-dialkylaminoethylimidazo[1,2-a]benzimidazoles
New water-soluble 3-acetyl-2-R-9-dialkylaminoethylimidazo[1,2-a]benzimidazoles were synthesized on the basis of previously described structure-effect relationships among imidazobenzimidazole derivatives with h...
-
Article
Synthesis and pharmacological activity of 3-(2,2,2-trichloro-1-hydroxyethyl)imidazo [1, 2-a]benzimidazole dihydrochlorides
Aseries of 3-(2,2,2-trichloro-1-hydroxyethyl)imidazo[1, 2-a]benzimidazole dihydrochlorides have been synthesized and their pharmacological properties have been studied. It is established that the synthesized comp...
-
Article
Synthesis and biological activity of N-acylmethyl derivatives of 9H-2,3-dihydroimidazo-and 10H-2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazoles and their reduction products
A series of N-acylmethyl derivatives of 9H-2,3-dihydroimidazo-and 10H-2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazoles and products of their reduction has been synthesized and their pharmacological properties ...
-
Article
Synthesis and Pharmacological Activity of 2-Methoxyphenyl-Substituted 9-Dialkylaminoethylimidazo[1,2-a]benzimidazoles
A series of 2-methoxyphenyl-9-dialkylaminoethyl derivatives of imidazo[1,2-a]benzimidazole have been synthesized and their pharmacological properties have been studied. Some of the synthesized compounds exhibi...
-
Article
Synthesis and Pharmacological Activity of 3-Aroyl- and 3-Hetaroylimidazo[1,2-a]benzimidazoles
-
Article
Synthesis and Pharmacological Activity of 2-(Hetaryl)imidazo[1,2-a]benzimidazoles