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  1. No Access

    Article

    Bioavailability of the Tablet Dosage Form of a Benzimidazole Derivative Possessing Antiplatelet Activity

    The bioavailability of the tablet dosage form of pharmaceutical substance RU-891, i.e., 9-(3,4-dihydroxyphenacyl)-2,3-dihydroimidazo[1,2-a]benzimidazole hydrobromide, was investigated. The main pharmacokinetic pa...

    A. A. Spasov, A. F. Kucheryavenko, K. A. Gaidukova… in Pharmaceutical Chemistry Journal (2022)

  2. No Access

    Article

    Quantitative Determination of Angipur Drug Substance in Blood Plasma by HPLC with Fluorescence Detection

    A quantitative determination method using HPLC with fluorescence detection for the xanthine derivative 3-methyl-8-(piperazin-1-yl)-7-(thietan-3-yl)-1-ethyl-1H-purine-2,6(3H,7H)-dione hydrochloride (Angipur drug s...

    L. A. Smirnova, A. F. Ryabukha, O. K. Abramov… in Pharmaceutical Chemistry Journal (2021)

  3. No Access

    Article

    Biopharmaceutical Study of an Injectable Dosage Form of the New Antiaggregant Substance 3-Methyl-8-(Piperazin-1-yl)-7-(Thietan-3-yl)-1-Ethyl-1H-Purine-2,6(3H,7H)-Dione Hydrochloride

    The pharmacokinetic parameters of the parent substance and the injectable dosage form of the new antiplatelet drug 3-methyl-8-(piperazin-1-yl)-7-(thietan-3-yl)-1-ethyl-1H-purine-2,6(3H,7H)-dione hydrochloride in ...

    L. A. Smirnova, A. A. Spasov, F. A. Khaliullin… in Pharmaceutical Chemistry Journal (2021)

  4. No Access

    Article

    Uracil Hydroxybenzamides as Potential Antidiabetic Prodrugs

    A series of N1, N3-bis-hydroxybenzoyl, -acetoxybenzoyl, and -methoxybenzoyl uracil derivatives were synthesized. All compounds were screened for the ability to rupture protein cross links and antiglycating, chela...

    A. K. Brel’, A. A. Spasov, S. V. Lisina, S. S. Popov… in Pharmaceutical Chemistry Journal (2019)

  5. No Access

    Article

    Synthesis and Pharmacological Activity of Trifluoromethyl-Containing Imidazo[1,2-A]Benzimidazoles

    A series of 2-(4-trifluoromethylphenyl)- and 2-trifluoromethyl-9-dialkylaminoalkylimidazo[1,2-a]benzimidazoles were synthesized for the first time by reacting 2-amino-1-dialkylaminoalkylbenzimidazoles and 2-bromo...

    O. N. Zhukovskaya, A. A. Spasov, T. A. Kuz’menko… in Pharmaceutical Chemistry Journal (2018)

  6. No Access

    Article

    The Search for Pharmacologically Active Compounds Among the 2-Dialkylaminobenzimidazoles

    Heating of substituted benzimidazole-2-sulfonic acids in the presence of excess quantities of secondary amines was used to synthesize dialkylaminobenzimidazoles. Experimental studies of potential antiarrhythmi...

    O. N. Zhukovskaya, V. A. Anisimova, A. A. Spasov… in Pharmaceutical Chemistry Journal (2017)

  7. No Access

    Article

    1-Substituted 2-Benzylaminobenzimidazoles with Phenyl Methoxyls: Synthesis, Computer Prediction, and Pharmacological Activity

    Condensation of 1-substituted 2-aminobenzimidazoles with aromatic aldehydes produced the corresponding azomethines, reduction of which by sodium borohydride afforded 1-substituted 2-benzylaminobenzimidazoles. ...

    O. N. Zhukovskaya, V. A. Anisimova, A. A. Spasov… in Pharmaceutical Chemistry Journal (2016)

  8. No Access

    Article

    Synthesis and Pharmacological Activity of Amino Alcohols of the Indole Series

    Opening of the oxirane ring in 1-oxiranylmethylindoles yielded new indole derivatives containing 1,2-amino alcohol residues at the nitrogen atom. Compounds were studied in vitro in relation to various types of...

    K. F. Suzdalev, A. A. Spasov, D. S. Yakovlev… in Pharmaceutical Chemistry Journal (2013)

  9. No Access

    Article

    Synthesis and pharmacological activity of amides of 2-amino-3-indolylacrylic acid

    Opening of the five-member ring of indolylmethyleneoxazolones with aliphatic amines was used to synthesize a series of amides of 2-amino-3-indolylacrylic acid. These compounds were studied in vitro in relation...

    A. A. Spasov, D. S. Yakovlev, K. F. Suzdalev… in Pharmaceutical Chemistry Journal (2013)

  10. No Access

    Article

    Synthesis and pharmacological activity of 3-(n,n-disubstituted)acetamide-1-r-2-aminobenzimidazolium chlorides

    A series of 3-(N,N-disubstituted)acetamide-1-R-2-aminobenzimidazolium chlorides were synthesized. Their pharmacological properties were studied. It was established that the synthesized substances decreased platel...

    V. A. Anisimova, A. A. Spasov, V. A. Kosolapov… in Pharmaceutical Chemistry Journal (2012)

  11. No Access

    Article

    Synthesis and pharmacological activity of salts of 3-acetyl-2-R-9-dialkylaminoethylimidazo[1,2-a]benzimidazoles

    New water-soluble 3-acetyl-2-R-9-dialkylaminoethylimidazo[1,2-a]benzimidazoles were synthesized on the basis of previously described structure-effect relationships among imidazobenzimidazole derivatives with h...

    V. A. Anisimova, A. A. Spasov, I. E. Tolpygin… in Pharmaceutical Chemistry Journal (2010)

  12. No Access

    Article

    Synthesis and pharmacological activity of 3-(2,2,2-trichloro-1-hydroxyethyl)imidazo [1, 2-a]benzimidazole dihydrochlorides

    Aseries of 3-(2,2,2-trichloro-1-hydroxyethyl)imidazo[1, 2-a]benzimidazole dihydrochlorides have been synthesized and their pharmacological properties have been studied. It is established that the synthesized comp...

    V. A. Anisimova, A. A. Spasov, V. A. Kosolapov… in Pharmaceutical Chemistry Journal (2009)

  13. No Access

    Article

    Synthesis and biological activity of N-acylmethyl derivatives of 9H-2,3-dihydroimidazo-and 10H-2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazoles and their reduction products

    A series of N-acylmethyl derivatives of 9H-2,3-dihydroimidazo-and 10H-2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazoles and products of their reduction has been synthesized and their pharmacological properties ...

    V. A. Anisimova, I. E. Tolpygin, A. A. Spasov… in Pharmaceutical Chemistry Journal (2006)

  14. No Access

    Article

    Synthesis and Pharmacological Activity of 2-Methoxyphenyl-Substituted 9-Dialkylaminoethylimidazo[1,2-a]benzimidazoles

    A series of 2-methoxyphenyl-9-dialkylaminoethyl derivatives of imidazo[1,2-a]benzimidazole have been synthesized and their pharmacological properties have been studied. Some of the synthesized compounds exhibi...

    V. A. Anisimova, A. A. Spasov, V. A. Kosolapov… in Pharmaceutical Chemistry Journal (2005)

  15. No Access

    Article

    Synthesis and Pharmacological Activity of 3-Aroyl- and 3-Hetaroylimidazo[1,2-a]benzimidazoles

    V. A. Anisimova, A. A. Spasov, O. V. Ostrovskii… in Pharmaceutical Chemistry Journal (2002)

  16. No Access

    Article

    Synthesis and Pharmacological Activity of 2-(Hetaryl)imidazo[1,2-a]benzimidazoles

    V. A. Anisimova, A. A. Spasov, A. F. Kucheryavenko… in Pharmaceutical Chemistry Journal (2002)