192 Result(s)
-
Article
Open AccessTargeting the transmembrane cytokine co-receptor neuropilin-1 in distal tubules improves renal injury and fibrosis
Neuropilin-1 (NRP1), a co-receptor for various cytokines, including TGF-β, has been identified as a potential therapeutic target for fibrosis. However, its role and mechanism in renal fibrosis remains elusive....
-
Article
Open AccessSCG5 and MITF may be novel markers of copper metabolism immunorelevance in Alzheimer’s disease
The slow-develo** neurological disorder Alzheimer’s disease (AD) has no recognized etiology. A bioinformatics investigation verified copper metabolism indicators for AD development. GEO contributed AD-relate...
-
Article
Open AccessElectrical switching of Ising-superconducting nonreciprocity for quantum neuronal transistor
Nonreciprocal quantum transport effect is mainly governed by the symmetry breaking of the material systems and is gaining extensive attention in condensed matter physics. Realizing electrical switching of the ...
-
Article
Open AccessPredictive value of triglyceride glucose index combined with neutrophil-to-lymphocyte ratio for major adverse cardiac events after PCI for acute ST-segment elevation myocardial infarction
Acute ST-segment elevation myocardial infarction (STEMI) is a severe cardiovascular disease that poses a significant threat to the life and health of patients. This study aimed to investigate the predictive va...
-
Article
Open AccessA new seven-axis robotic-assisted total hip arthroplasty system improves component positioning: a prospective, randomized, multicenter study
This study compared the radiologic and clinical outcomes of a new seven-axis robotic-assisted total hip arthroplasty (THA) and conventional THA. Hundred and four patients were randomly assigned to two groups—t...
-
Article
Open AccessSmart diabetic foot ulcer scoring system
Current assessment methods for diabetic foot ulcers (DFUs) lack objectivity and consistency, posing a significant risk to diabetes patients, including the potential for amputations, highlighting the urgent nee...
-
Article
Open AccessIdentification of candidate biomarkers for GBM based on WGCNA
Glioblastoma multiforme (GBM), the most aggressive form of primary brain tumor, poses a considerable challenge in neuro-oncology. Despite advancements in therapeutic approaches, the prognosis for GBM patients ...
-
Article
Open AccessFlash heating process for efficient meat preservation
Maintaining food safety and quality is critical for public health and food security. Conventional food preservation methods, such as pasteurization and dehydration, often change the overall organoleptic qualit...
-
Article
Open AccessMutation characteristics and molecular evolution of ovarian metastasis from gastric cancer and potential biomarkers for paclitaxel treatment
Ovarian metastasis is one of the major causes of treatment failure in patients with gastric cancer (GC). However, the genomic characteristics of ovarian metastasis in GC remain poorly understood. In this study...
-
Article
Open AccessFunctional alterations of the brain default mode network and somatosensory system in trigeminal neuralgia
Map** the localization of the functional brain regions in trigeminal neuralgia (TN) patients is still lacking. The study aimed to explore the functional brain alterations and influencing factors in TN patien...
-
Article
Open AccessExtra-articular screw placement strategy in Stoppa approach based on three-dimensional reconstruction model
The study aimed to explore an extra-articular screw placement strategy in Stoppa approach. Radiographic data of patients who underwent pelvic computed tomography from January 2016 to June 2017 were imported in...
-
Article
Open AccessAtomic-scale visualization of the interlayer Rydberg exciton complex in moiré heterostructures
Excitonic systems, facilitated by optical pum**, electrostatic gating or magnetic field, sustain composite particles with fascinating physics. Although various intriguing excitonic phases have been revealed ...
-
Article
Open AccessA novel multidrug-resistant cell line from a Chinese patient with pancreatic ductal adenocarcinoma
Chemotherapy resistance poses clinical challenges in pancreatic cancer treatment. Develo** cell lines resistant to chemotherapy is crucial for investigating drug resistance mechanisms and identifying alterna...
-
Article
Open AccessReconfigurable optoelectronic transistors for multimodal recognition
Biological nervous system outperforms in both dynamic and static information perception due to their capability to integrate the sensing, memory and processing functions. Reconfigurable neuromorphic transistor...
-
Article
Open AccessDeficiency of the HGF/Met pathway leads to thyroid dysgenesis by impeding late thyroid expansion
The mechanisms of bifurcation, a key step in thyroid development, are largely unknown. Here we find three zebrafish lines from a forward genetic screening with similar thyroid dysgenesis phenotypes and identif...
-
Article
Open AccessDON6D: a decoupled one-stage network for 6D pose estimation
The six-dimensional (6D) pose object estimation is a key task in robotic manipulation and gras** scenes. Many existing two-stage solutions with a slow inference speed require extra refinement to handle the c...
-
Article
Open AccessAssociations between corneal curvature and other anterior segment biometrics in young myopic adults
To investigate the associations between corneal curvature (CC) and other anterior segment biometrics in young myopic adults. In this retrospective multi-center study, 7893 young myopic adults were included. CC...
-
Article
Open AccessClinicopathological characteristics and prognosis in patients with monoclonal gammopathy and renal damage in central China: a multicenter retrospective cohort study
Renal involvement is common in monoclonal gammopathy (MG); however, the same patient may have both MG and non-paraprotein-associated renal damage. Accordingly, distinguishing the cause of renal damage is neces...
-
Article
Open AccessExtreme Li-Mg selectivity via precise ion size differentiation of polyamide membrane
Achieving high selectivity of Li+ and Mg2+ is of paramount importance for effective lithium extraction from brines, and nanofiltration (NF) membrane plays a critical role in this process. The key to achieving hig...
-
Article
Open AccessA three-level regulatory mechanism of the aldo-keto reductase subfamily AKR12D
Modulation of protein function through allosteric regulation is central in biology, but biomacromolecular systems involving multiple subunits and ligands may exhibit complex regulatory mechanisms at different ...