18 Result(s)
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Biomedicine
Biomedicine, general
Neurosciences
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Fruquintinib plus paclitaxel versus placebo plus paclitaxel for gastric or gastroesophageal junction adenocarcinoma: the randomized phase 3 FRUTIGA trial
The vascular endothelial growth factor pathway plays a key role in the pathogenesis of gastric cancer. In the multicenter, double-blind phase 3 FRUTIGA trial, 703 patients with advanced gastric or gastroesopha...
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Open AccessDual-energy lattice-tip ablation system for persistent atrial fibrillation: a randomized trial
Clinical outcomes of catheter ablation for atrial fibrillation (AF) are suboptimal due, in part, to challenges in achieving durable lesions. Although focal point-by-point ablation allows for the creation of an...
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Open AccessScreening and diagnosis of cardiovascular disease using artificial intelligence-enabled cardiac magnetic resonance imaging
Cardiac magnetic resonance imaging (CMR) is the gold standard for cardiac function assessment and plays a crucial role in diagnosing cardiovascular disease (CVD). However, its widespread application has been l...
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First-line sugemalimab with chemotherapy for advanced esophageal squamous cell carcinoma: a randomized phase 3 study
Although antiprogrammed death 1 antibody plus chemotherapy has recently been approved for first-line esophageal squamous cell carcinoma (ESCC), antiprogrammed death-ligand 1 antibody may offer another combinat...
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Open AccessReal-world implementation of a multilevel interventions program to prevent mother-to-child transmission of HBV in China
Reducing hepatitis B virus (HBV) mother-to-child transmission (MTCT) is a fundamental step toward the HBV elimination goal. The multicentred, multilevel SHIELD program aimed to use an intense intervention pack...
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Semantic and syntactic processing of emojis in sentential intermediate positions
The current study investigated the neuro mechanisms of emoji processing as sentence predicate in written context. In the hybrid textuality which is more cognitively engaging, emojis in sentential intermediate ...
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The airway microbiome mediates the interaction between environmental exposure and respiratory health in humans
Exposure to environmental pollution influences respiratory health. The role of the airway microbial ecosystem underlying the interaction of exposure and respiratory health remains unclear. Here, through a prov...
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Open AccessGenome-wide association study using whole-genome sequencing identifies risk loci for Parkinson’s disease in Chinese population
Genome-wide association studies (GWASs) have identified numerous susceptibility loci for Parkinson’s disease (PD), but its genetic architecture remains underexplored in populations of non-European ancestry. To...
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Leukocyte telomere length in children born following blastocyst-stage embryo transfer
Perinatal and childhood adverse outcomes associated with assisted reproductive technology (ART) has been reported, but it remains unknown whether the initial leukocyte telomere length (LTL), which is an indica...
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Open AccessDorzagliatin add-on therapy to metformin in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled phase 3 trial
Metformin, the first-line therapy for type 2 diabetes (T2D), decreases hepatic glucose production and reduces fasting plasma glucose levels. Dorzagliatin, a dual-acting orally bioavailable glucokinase activato...
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A neuroimaging biomarker for striatal dysfunction in schizophrenia
Mounting evidence suggests that function and connectivity of the striatum is disrupted in schizophrenia1–5. We have developed a new hypothesis-driven neuroimaging biomarker for schizophrenia identification, progn...
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Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer
Targeting tyrosine kinase receptors that share the feedback inhibitor PTPN12 leads to broad spectrum therapeutic suppression of triple-negative breast cancer.
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Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats
A novel stainless-steel pin has been engineered with a pure magnesium core that promotes improved fracture healing in rats by inducing local production of a key neuropeptide for osteogenesis.
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Default network connectivity decodes brain states with simulated microgravity
With great progress of space navigation technology, it becomes possible to travel beyond Earth’s gravity. So far, it remains unclear whether the human brain can function normally within an environment of micr...
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Physical basis of apparent pore dilation of ATP-activated P2X receptor channels
The prevailing view for purinergic P2X receptor channels is that their ion conduction pores dilate upon prolonged activation. This study finds that the hallmark shift in equilibrium potential observed with pro...
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Autophagy regulates endothelial cell processing, maturation and secretion of von Willebrand factor
In the process of autophagy, cellular constituents are degraded and recycled. Toren Finkel and his colleagues show that this process also regulates the secretion of a key blood-clotting protein by endothelial ...
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Oral tolerance to food-induced systemic anaphylaxis mediated by the C-type lectin SIGNR1
A C-type lectin receptor, SIGNR-1, helps dendritic cells in the gut induce oral tolerance. Sugar-modified antigens might therefore be used to induce oral tolerance to food-induced anaphylaxis.
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Gating the pore of P2X receptor channels
Trimeric P2X receptor channels are activated by ATP and function in neural signaling, pain transmission and inflammation-based pathways. Cysteine scanning analysis of the transmembrane regions revealed that th...
