19 Result(s)

Article

Correction to: Thymectomy and Risk of Generalization in Patients with Ocular Myasthenia Gravis: a Multicenter Retrospective Cohort Study

Huanhuan Li, Zhe Ruan, Feng Gao, Hongyu Zhou, Rong**g Guo, Chao Sun… in Neurotherapeutics (2021)

Article

Correction to: Comparative Effectiveness and Tolerability of the Pharmacology of Monoclonal Antibodies Targeting the Calcitonin Gene-Related Peptide and Its Receptor for the Prevention of Chronic Migraine: a Network Meta-analysis of Randomized Controlled Trials

Chun-Pai Yang, Bing-Yan Zeng, Ching-Mao Chang, Po-Hsuan Shih… in Neurotherapeutics (2021)

Article

Thymectomy and Risk of Generalization in Patients with Ocular Myasthenia Gravis: A Multicenter Retrospective Cohort Study

This study aims to investigate the association between thymectomy and the risk of generalization in patients with ocular myasthenia gravis (MG). Data on patients with ocular MG from seven neurological centers ...

Huanhuan Li, Zhe Ruan, Feng Gao, Hongyu Zhou, Rong**g Guo, Chao Sun… in Neurotherapeutics (2021)

Article

A Compound Mitigates Cancer Pain and Chemotherapy-Induced Neuropathic Pain by Dually Targeting nNOS-PSD-95 Interaction and GABA_A Receptor

Metastatic bone pain and chemotherapy-induced peripheral neuropathic pain are the most common clinical symptoms in cancer patients. The current clinical management of these two disorders is ineffective and/or ...

Wei Wei, Weili Liu, Shibin Du, Gokulapriya Govindarajalu… in Neurotherapeutics (2021)

Article

Comparative Effectiveness and Tolerability of the Pharmacology of Monoclonal Antibodies Targeting the Calcitonin Gene-Related Peptide and Its Receptor for the Prevention of Chronic Migraine: a Network Meta-analysis of Randomized Controlled Trials

Monoclonal antibodies (mAbs) acting on the calcitonin gene-related peptide (CGRP) or on its receptor are new therapeutic biologics to prevent chronic migraine (CM). Four mAbs acting on the CGRP or on its recep...

Chun-Pai Yang, Bing-Yan Zeng, Ching-Mao Chang, Po-Hsuan Shih… in Neurotherapeutics (2021)

Article

Effect of Pharmacological Inhibition of Fat-Mass and Obesity-Associated Protein on Nerve Trauma-Induced Pain Hypersensitivities

Genetic knockout or knockdown of fat-mass and obesity-associated protein (FTO), a demethylase that participates in RNA N⁶-methyladenosine modification in injured dorsal root ganglion (DRG), has been demonstrated ...

Bi-**n Zheng, **nying Guo, Sfian Albik, Jean Eloy, Yuan-**ang Tao in Neurotherapeutics (2021)

Article

Neuroprotection of Exendin-4 by Enhanced Autophagy in a Parkinsonian Rat Model of α-Synucleinopathy

Glucagon-like peptide-1 (GLP-1) receptor stimulation ameliorates parkinsonian motor and non-motor deficits in both experimental animals and patients; however, the disease-modifying mechanisms of GLP-1 receptor...

Lu-Lu Bu, Yi-Qi Liu, Yan Shen, Yun Fan, Wen-Bo Yu, Dong-Lang Jiang… in Neurotherapeutics (2021)

Article

CREB Participates in Paclitaxel-Induced Neuropathic Pain Genesis Through Transcriptional Activation of Dnmt3a in Primary Sensory Neurons

Chemotherapy-induced peripheral neuropathic pain (CIPNP) often occurs in cancer patients treated with antineoplastic drugs. Therapeutic management of CIPNP is very limited, at least in part due to the largely ...

Yong Yang, **g Wen, Bixin Zheng, Shaogen Wu, Qingxiang Mao… in Neurotherapeutics (2021)

Article

Neuromodulation, Specialized Proresolving Mediators, and Resolution of Pain

The current crises in opioid abuse and chronic pain call for the development of nonopioid and nonpharmacological therapeutics for pain relief. Neuromodulation-based approaches, such as spinal cord stimulation,...

Xueshu Tao, Michael S. Lee, Christopher R. Donnelly, Ru-Rong Ji in Neurotherapeutics (2020)

Article

Chronic morphine-mediated upregulation of high mobility group box 1 in the spinal cord contributes to analgesic tolerance and hyperalgesia in rats

Analgesic tolerance and hyperalgesia hinder the long-term utility of opioids. We examined whether spinal high mobility group box 1 (HMGB1) is involved in morphine tolerance and its underlying mechanisms by usi...

Junliang Qian, Yanan Zhu, Liying Bai, Yan Gao, Mingjun Jiang, Fei **ng… in Neurotherapeutics (2020)

Article

Activation of Melanocortin 1 Receptor Attenuates Early Brain Injury in a Rat Model of Subarachnoid Hemorrhage viathe Suppression of Neuroinflammation through AMPK/TBK1/NF-κB Pathway in Rats

Neuroinflammation plays a vital role in early brain injury (EBI) following subarachnoid hemorrhage (SAH). The hypothesis of this study was that activation of melanocortin 1 receptor (MC1R) with BMS-470539 atte...

Weilin Xu, Jun Mo, Umut Ocak, Zachary D. Travis, Budbazar Enkhjargal… in Neurotherapeutics (2020)

Article

Correction to: Transcranial Magneto-Acoustic Stimulation Improves Neuroplasticity in Hippocampus of Parkinson’s Disease Model Mice

The authors would like to correct X. Zhou’s grant number from the National Natural Science Foundation of China to 81601633.

Yuexiang Wang, Lina Feng, Shikun Liu, **aoqing Zhou, Tao Yin… in Neurotherapeutics (2019)

Article

Transcranial Magneto-Acoustic Stimulation Improves Neuroplasticity in Hippocampus of Parkinson’s Disease Model Mice

In this study, we have, for the first time, demonstrated the beneficial effects of transcranial magneto-acoustic stimulation (TMAS), a technique based on focused ultrasound stimulation within static magnetic f...

Yuexiang Wang, Lina Feng, Shikun Liu, **aoqing Zhou, Tao Yin… in Neurotherapeutics (2019)

Article

Characterization and Imaging of Lipid-Shelled Microbubbles for Ultrasound-Triggered Release of Xenon

Xenon (Xe) is a bioactive gas capable of reducing and stabilizing neurologic injury in stroke. The goal of this work was to develop lipid-shelled microbubbles for xenon loading and ultrasound-triggered release...

Himanshu Shekhar, Arunkumar Palaniappan, Tao Peng, Maxime Lafond… in Neurotherapeutics (2019)

Article

TET1 Overexpression Mitigates Neuropathic Pain Through Rescuing the Expression of μ-Opioid Receptor and Kv1.2 in the Primary Sensory Neurons

Peripheral nerve injury downregulates the expression of the μ-opioid receptor (MOR) and voltage-gated potassium channel subunit Kv1.2 by increasing their DNA methylation in the dorsal root ganglion (DRG). Ten-...

Qiang Wu, Guihua Wei, Fengtao Ji, Shushan Jia, Shaogen Wu, **nying Guo… in Neurotherapeutics (2019)

Article

Inhibition of MyD88 Signaling Skews Microglia/Macrophage Polarization and Attenuates Neuronal Apoptosis in the Hippocampus After Status Epilepticus in Mice

Inflammation is implicated in epileptogenesis. Activated microglia and macrophages (MG/MΦ) are found in the brains of patients with epilepsy-related diseases and animal models of epilepsy. It is not yet known ...

**-Tao Liu, Sheng-** Wu, Hua Zhang, Fang Kuang in Neurotherapeutics (2018)

Article

iTRAQ-Based Quantitative Proteomics Reveals the New Evidence Base for Traumatic Brain Injury Treated with Targeted Temperature Management

This study aimed to investigate the effects of targeted temperature management (TTM) modulation on traumatic brain injury (TBI) and the involved mechanisms using quantitative proteomics technology. SH-SY5Y and...

Shi-**ang Cheng, Zhong-Wei Xu, Tai-Long Yi, Hong-Tao Sun, Cheng Yang… in Neurotherapeutics (2018)

Article

hVMAT2: A Target of Individualized Medication for Parkinson’s Disease

Vesicular monoamine transporter 2 (VMAT2) is responsible for sequestering cytosolically toxic dopamine into intracellular secretory vesicles. Animal genetic studies have suggested that reduced VMAT2 activity c...

Nian **ong, Nuomin Li, Eden Martin, **long Yu, Jie Li, **g Liu… in Neurotherapeutics (2016)