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  1. No Access

    Article

    m6A demethylation of FOSL1 mRNA protects hepatoma cells against necrosis under glucose deprivation

    Stress-adaptive mechanisms enabling cancer cells to survive under glucose deprivation remain elusive. N6-methyladenosine (m6A) modification plays important roles in determining cancer cell fate and cellular stres...

    Chun-Rui Wang, Jun-Hua Gong, Zhi-Bo Zhao, Qian Zhu… in Cell Death & Differentiation (2024)

  2. Article

    Open Access

    Thrombomodulin reduces α-synuclein generation and ameliorates neuropathology in a mouse model of Parkinson’s disease

    The neurotoxic α-synuclein (α-syn) oligomers play an important role in the occurrence and development of Parkinson’s disease (PD), but the factors affecting α-syn generation and neurotoxicity remain unclear. W...

    **ao-yun Niu, **-xiu **e, Hou-zhen Tuo, Cui-** Lv, Ya-ru Huang… in Cell Death Discovery (2024)

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  3. Article

    Open Access

    IP3R2-mediated Ca2+ release promotes LPS-induced cardiomyocyte pyroptosis via the activation of NLRP3/Caspase-1/GSDMD pathway

    Pyroptosis plays a crucial role in sepsis, and the abnormal handling of myocyte calcium (Ca2+) has been associated with cardiomyocyte pyroptosis. Specifically, the inositol 1,4,5-trisphosphate receptor type 2 (IP...

    Qing-Rui Wu, Hui Yang, Hui-Dan Zhang, Yong-Jiang Cai… in Cell Death Discovery (2024)

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  4. Article

    Open Access

    Targeting the up-regulated CNOT3 reverses therapeutic resistance and metastatic progression of EGFR-mutant non-small cell lung cancer

    Lung cancer is the leading cause of cancer-related mortality worldwide. CNOT3, a subunit of the CCR4-NOT complex, has recently been suggested to be overexpressed in lung cancer and involved in tumor malignancy...

    Lin **g, Meng-En Zhai, Mei-Rui Qian, Yi-Ming Li, Ming-Wei Han… in Cell Death Discovery (2023)

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  5. No Access

    Article

    RUNDC1 inhibits autolysosome formation and survival of zebrafish via clas** ATG14-STX17-SNAP29 complex

    Autophagy serves as a pro-survival mechanism for a cell or a whole organism to cope with nutrient stress. Our understanding of the molecular regulation of this fusion event remains incomplete. Here, we identif...

    Rui Zhang, Yuyan Yang, Chao He, **n Zhang, Vincenzo Torraca… in Cell Death & Differentiation (2023)

  6. No Access

    Article

    Prolonged hypoxia alleviates prolyl hydroxylation-mediated suppression of RIPK1 to promote necroptosis and inflammation

    The prolyl hydroxylation of hypoxia-inducible factor 1α (HIF-1α) mediated by the EGLN–pVHL pathway represents a classic signalling mechanism that mediates cellular adaptation under hypoxia. Here we identify RI...

    Tao Zhang, Daichao Xu, Jian** Liu, Min Wang, Li-Juan Duan, Min Liu… in Nature Cell Biology (2023)

  7. No Access

    Article

    Establishment and comprehensive analysis of a new human cell line (NK-NJ) with NK-cell characteristics established from extranodal natural killer cell lymphoma/leukemia

    Extranodal NK/T cell lymphoma, nasal type (ENKTL) is an aggressive and heterogeneous disease. With standard treatment containing pegaspargase-based regimen, patients who were resistant to pegaspargase have rap...

    **-Hua Liang, Wei-Ting Wang, Kai-**n Du, Tong-Yao **ng, Yan Wang, Hui Wang… in Human Cell (2023)

  8. No Access

    Article

    Serine protease HtrA2/Omi regulates adaptive mitochondrial reprogramming in the brain cortex after ischemia/reperfusion injury via UCP2-SIRT3-PGC1 axis

    This study is to investigate the underlying mechanisms of mitochondrial quality control (MQC) regulated by HtrA2/Omi during ischemia/reperfusion (I/R). We utilized the mnd2 mouse model, which has a missense mutat...

    Hao Meng, Lian-Kun Sun, **g Su, Wan-Yu Yan, Yao **, **n Luo, **an-Rui Jiang… in Human Cell (2022)

  9. No Access

    Article

    TGF-β induces assembly of a Smad2–Smurf2 ubiquitin ligase complex that targets SnoN for degradation

    The receptor-regulated Smad proteins are essential intracellular mediators of signal transduction by the transforming growth factor-β (TGF-β) superfamily of growth factors and are also important as regulators ...

    Shirin Bonni, Hong-Rui Wang, Carrie G. Causing, Peter Kavsak… in Nature Cell Biology (2001)