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Article
Open AccessEmergent normal fluid in the superconducting ground state of overdoped cuprates
The microscopic mechanism for the disappearance of superconductivity in overdoped cuprates is still under heated debate. Here we use scanning tunneling spectroscopy to investigate the evolution of quasiparticl...
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Article
Open AccessAerobic oxidation of methane significantly reduces global diffusive methane emissions from shallow marine waters
Methane is supersaturated in surface seawater and shallow coastal waters dominate global ocean methane emissions to the atmosphere. Aerobic methane oxidation (MOx) can reduce atmospheric evasion, but the magni...
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Article
Open AccessGenomic signatures define three subtypes of EGFR-mutant stage II–III non-small-cell lung cancer with distinct adjuvant therapy outcomes
The ADJUVANT study reported the comparative superiority of adjuvant gefitinib over chemotherapy in disease-free survival of resected EGFR-mutant stage II–IIIA non-small cell lung cancer (NSCLC). However, not all ...
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Article
Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B
CpG methylation by de novo DNA methyltransferases (DNMTs) 3A and 3B is essential for mammalian development and differentiation and is frequently dysregulated in cancer1. These two DNMTs preferentially bind to nuc...
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Article
Open AccessBacteria are important dimethylsulfoniopropionate producers in marine aphotic and high-pressure environments
Dimethylsulfoniopropionate (DMSP) is an important marine osmolyte. Aphotic environments are only recently being considered as potential contributors to global DMSP production. Here, our Mariana Trench study re...
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Article
Open AccessAutophagy deficiency promotes triple-negative breast cancer resistance to T cell-mediated cytotoxicity by blocking tenascin-C degradation
Most triple-negative breast cancer (TNBC) patients fail to respond to T cell-mediated immunotherapies. Unfortunately, the molecular determinants are still poorly understood. Breast cancer is the disease geneti...
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Article
Open AccessStructure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling
Formylpeptide receptors (FPRs) as G protein-coupled receptors (GPCRs) can recognize formylpeptides derived from pathogens or host cells to function in host defense and cell clearance. In addition, FPRs, especi...
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Article
Observation of the nonlinear Hall effect under time-reversal-symmetric conditions
The electrical Hall effect is the production, upon the application of an electric field, of a transverse voltage under an out-of-plane magnetic field. Studies of the Hall effect have led to important breakthro...
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Article
Open AccessElastic pseudospin transport for integratable topological phononic circuits
Precise control of solid-state elastic waves’ mode content and coherence is of great use nowadays in reinforcing mechanical energy harvesting/storage, nondestructive material testing, wave-matter interaction, ...
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Article
Open AccessPublisher Correction: Fungus-larva relation in the formation of Cordyceps sinensis as revealed by stable carbon isotope analysis
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
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Open AccessFungus-larva relation in the formation of Cordyceps sinensis as revealed by stable carbon isotope analysis
For more than one thousand years, Cordyceps sinensis has been revered as a unique halidom in the Qinghai-Tibetan Plateau for its mysterious life history and predominant medicinal values. This mysterious fungus-la...
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Article
Open AccessSerum Metabolomics Analysis Reveals a Distinct Metabolic Profile of Patients with Primary Biliary Cholangitis
Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease associated with profound metabolic changes. The purpose of this study was to identify a distinctive metabolic signature from the training...
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Open AccessIsolation and Characterization of Encephalomyocarditis Virus from Dogs in China
Encephalomyocarditis virus (EMCV) is as a potential zoonotic agent with a wide host range. Here, we describe an EMC virus isolate, identified as EMCV C15, which was successfully obtained from the serum of dogs...
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Article
Open AccessStatus of HBsAg seroprevalence in 15 million rural couples in China: a cross-sectional study
A cross-sectional analysis of prevalence of hepatitis B virus infection (HBV) among rural couples was conducted between 2010 and 2014. Serologic HBV markers, including hepatitis B surface antigen (HBsAg) and e...
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Article
Open AccessWater use efficiency in a primary subtropical evergreen forest in Southwest China
We calculated water use efficiency (WUE) using measures of gross primary production (GPP) and evapotranspiration (ET) from five years of continuous eddy covariance measurements (2009–2013) obtained over a prim...
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Article
Open AccessCholecystectomy is associated with higher risk of early recurrence and poorer survival after curative resection for early stage hepatocellular carcinoma
Although cholecystectomy has been reported to be associated with increased risk of develo** hepatocellular carcinoma (HCC), the association between cholecystectomy and prognosis of HCC patients underwent cur...
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Article
Open AccessSOX7 co-regulates Wnt/β-catenin signaling with Axin-2: both expressed at low levels in breast cancer
SOX7 as a tumor suppressor belongs to the SOX F gene subfamily and is associated with a variety of human cancers, including breast cancer, but the mechanisms involved are largely unclear. In the current study,...
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Article
Open AccessSignatures of the Adler–Bell–Jackiw chiral anomaly in a Weyl fermion semimetal
Weyl semimetals provide the realization of Weyl fermions in solid-state physics. Among all the physical phenomena that are enabled by Weyl semimetals, the chiral anomaly is the most unusual one. Here, we repor...
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Article
Open AccessStructural insights into HetR−PatS interaction involved in cyanobacterial pattern formation
The one-dimensional pattern of heterocyst in the model cyanobacterium Anabaena sp. PCC 7120 is coordinated by the transcription factor HetR and PatS peptide. Here we report the complex structures of HetR binding ...
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Open AccessThree-dimensional periodic supramolecular organic framework ion sponge in water and microcrystals
Self-assembly has emerged as a powerful approach to generating complex supramolecular architectures. Despite there being many crystalline frameworks reported in the solid state, the construction of highly solu...